心脉隆注射液对慢性肾功能不全合并心力衰竭患者尿量及血钾的影响

Effects of Xinmailong injection on urine volume and serum potassium level in the patients with chronic renal insufficiency combined with heart failure

目的研究心脉隆注射液对慢性肾功能不全(CRI)合并心力衰竭(HF)患者尿量及血钾的影响。方法选择河北省保定市第一中心医院2017年3月至2018年11月诊治的80例CRI合并HF患者作为研究对象,随机信封法均分为常规组和心脉隆组,各40例。常规组给予常规西药治疗,心脉隆组在其基础上加用心脉隆注射液。比较2组患者治疗前后心功能指标、肾功能指标、24 h尿量和血钾水平,并评估疗效和安全性。结果心脉隆组患者临床疗效为92.50%,显著高于常规组的75.00%(P<0.05);2组患者治疗后心功能指标水平与治疗前比较差异均有统计学意义(P<0.05),且治疗后心脉隆组患者左心室射血分数(LVEF)高于常规组,氨基N端B型尿钠肽(NT-proBNP)和肌钙蛋白T(cTnT)水平显著低于常规组,差异均有统计学意义(P<0.05);2组患者治疗后血清肌肝(SCr)和胱抑素(CysC)水平较治疗前均显著降低,且治疗后心脉隆组患者上述指标水平显著低于常规组,差异均有统计学意义(P<0.05);2组患者治疗后24 h尿量和血钾水平与治疗前比较差异均有统计学意义(P<0.05),且治疗后心脉隆组患者24 h尿量高于常规组,血钾水平显著低于常规组,差异均有统计学意义(P<0.05);2组不良反应发生率比较差异无统计学意义(P>0.05)。结论心脉隆注射液应用于CRI合并HF患者治疗,具有较好的疗效和安全性,可有效改善患者心肌功能和肾功能。

Objective To study the effects of Xinmailong injection on urine volume and serum potassium level in the patients with chronic renal insufficiency(CRI)combined with heart failure(HF).Methods A total of 80 patients with CRI plus HF who were diagnosed and treated in the hospital from March 2017 to November 2018 were enrolled as research subjects,and were divided into the routine group and the Xinmailong group,each consisting of 40 patients.The routine group was treated with Western medicine,while the Xinmailong group received Xinmailong injection in addition to Western medicine.The cardiac function and renal function indexes,24-h urine volume and serum potassium level before and after treatment were compared between the 2 groups.The curative effect and medication safety were evaluated also.Results The curative effect in the Xinmailong group was significantly higher than that in the routine group(92.50%vs 75.00%)(P<0.05).There were significant differences in the levels of cardiac function indexes of both groups before and after treatment.Following treatment,the level of left ventricular ejection fraction(LVEF)in the Xinmailong group was higher than that in the routine group,while the levels of NT-proBNP and cTnT were significantly lower than those in the routine group,with statistical significance(P<0.05).After treatment,the levels of SCr and CysC in both groups significantly decreased,with that in the Xinmailong group being significantly lower than that in the routine group,and statistical significance could be seen when comparisons were made between the 2 groups(P<0.05).There were significant differences in the 24 h urine volume and serum potassium level in both groups,as compared with those before and after treatment,and 24 h urine volume after treatment in the Xinmailong group was higher than that in the routine group,while the level of serum potassium in the former was significantly lower than that in the latter(P<0.05).However,there were no significant differences in the rate of adverse reactions,when comparisons were made between the 2 groups(P<0.05).Conclusion The Xinmailong injection displayed good safety and curative effect in the treatment of patients with CRI plus HF,and it could effectively improve patients′myocardial function and renal function.