抗生素在肿瘤发生发展及免疫治疗中的作用

Role of antibiotics in tumor development and immunotherapy

近年来,以免疫检查点抑制剂(ICI)为代表性药物的肿瘤免疫治疗成为晚期恶性肿瘤重要的治疗方法。临床前研究发现,肠道微生物群紊乱会降低应用ICI患者的临床获益。最新的数据表明,抗生素可能通过改变肠道微生物群的丰度及组成进一步影响肿瘤的发生发展及免疫治疗疗效。总结抗生素在晚期恶性肿瘤免疫治疗中的作用,可为优化晚期肿瘤患者治疗策略提供新思路。

In recent years,immunotherapy with immune checkpoint inhibitor(ICI)as the representative drug has become an important treatment method for advanced malignant tumors.Preclinical studies have found that disorders of the gut microbiota can reduce the clinical benefit of patients treated with ICI.The latest data indicate that antibiotics may further affect the occurrence and development of tumors and the efficacy of immunotherapy by changing the abundance and composition of intestinal microbiota.To sum up the role of anti-biotics in the immunotherapy of advanced malignant tumor may provide a new idea for the optimization of treatment strategies for patients with advanced cancer.