心脏干预治疗在老年急性心肌梗死病人中的疗效及对炎症因子和心室重构的影响

Effect of cardiac intervention on inflammatory factors and ventricular remodeling in elderly patients with acute myocardial infarction

目的探讨心脏干预治疗在老年急性心肌梗死病人中的临床疗效及对炎症因子、心室重构的影响。方法选择2018年3月至2019年3月老年急性心肌梗死病人88例作为对象,分为对照组(n=44)和观察组(n=44)。对照组给予介入治疗,观察组在对照组基础上联合心脏干预治疗,治疗4周后对病人效果进行评估,比较2组心功能水平、炎症因子水平、心室重构及心血管并发症发生率。结果观察组治疗后4周LVEF水平高于对照组,左心室舒张末内径(LVEDD)、左心室收缩末内径(LVESD)、BNP、细胞可溶性凋亡相关因子(s-FAS)、IL-6及hs-CRP水平均低于对照组(P<0.05);观察组治疗后4周总体心血管并发症发生率低于对照组(P<0.05)。结论心脏干预治疗能提高老年急性心肌梗死病人心功能水平,改善心室重构,降低炎症因子水平及介入治疗并发症发生率,值得推广应用。

Objective To investigate the clinical efficacy of cardiac intervention therapy in the elderly patients with acute myocardial infarction and the influence on inflammatory factors and ventricular remodeling.Methods A total of 88 elderly patients with acute myocardial infarction from March 2018 to March 2019 were divided into control group(n=44)and observation group(n=44).The control group was given interventional therapy,and the observation group received cardiac intervention on the basis of the control group.The effect was evaluated after 4 weeks of treatment.The levels of cardiac function,inflammatory factors,ventricular remodeling and incidence rate of cardiovascular complications were compared between the two groups.Results The level of left ventricular ejection fraction(LVEF)in the observation group was higher than that of the control group 4 weeks after treatment(P<0.05);The levels of left ventricular end diastolic diameter(LVEDD)and left ventricular end systolic diameter(LVESD)in the observation group were lower than those in the control group(P<0.05).The levels of the inflammatory factors including B-type natriuretic peptide(BNP),soluble apoptosis related factor(s-fas),interleukin-6(IL-6)and high sensitivity C-reactive protein(hs-CRP)in the observation group were lower than those in the control group(P<0.05).The incidence rate of cardiovascular complications including recurrent angina pectoris,heart failure,cardiogenic shock,arrhythmia and recurrent myocardial infarction in the observation group was lower than that in the control group(P<0.05).Conclusions Cardiac intervention in the elderly patients with acute myocardial infarction can improve the level of cardiac function and the ventricular remodeling,and reduce the level of inflammatory factors and the incidence rate of interventional therapy complications,which is worthy of promotion and application.