乳腺癌患者骨转移与血清抗酒石酸酸性磷酸酶、PINP、β-CTX水平的关系研究

Study on the Relationship Between Bone Metastasis and Serum Anti-Tartrate Acid Phosphatase,PINP,β-CTX in Patients with Breast Cancer

目的研究乳腺癌患者骨转移与血清抗酒石酸酸性磷酸酶(TRACP)、血清Ⅰ型前胶原N-端前肽(PINP)、Ⅰ型胶原羧基端肽β特殊序列(β-CTX)水平的关系。方法回顾性分析120例乳腺癌患者临床资料,根据肿瘤是否发生骨转移分为研究组(69例)和对照组(51例),同时采用Soloway分级标准将研究组患者分为A、B、C三个亚组,检测所有患者TRACP、PINP和β-CTX水平,并分析三者与骨转移之间的关系。结果研究组血清TRACP、PINP和β-CTX水平明显高于对照组(P<0.05);C组患者上述血清水平均明显高于B组和A组,B组高于A组(P<0.05);血清TRACP、PINP和β-CTX水平均与乳腺癌患者骨转移程度呈正相关(P<0.05)。结论血清TRACP、PINP和β-CTX水平与乳腺癌患者骨转移程度呈正相关,可为乳腺癌患者骨转移诊断提供有价值的参考。

Objective To study the relationship between bone metastasis and serum anti-tartrate acid phosphatase(TRACP),PINP andβ-CTX levels in breast cancer patients.Methods The clinical data of 120 breast cancer patients diagnosed and treated were retrospectively analyzed.They were divided into study group(occurrence,69 cases)and control group(non-occurrence,51 cases)based on whether tumor metastasis occurred.At the same time,the patients of the study group were divided into three subgroups A,B,and C using the Soloway classification standard.The TRACP,PINP,andβ-CTX levels were measured in all patients,and the relationship between the three and bone metastasis was analyzed.Results The serum levels of TRACP,PINP andβ-CTX in the study group were significantly higher than those in the control group(P<0.05);the serum levels of the patients in group C were significantly higher than those in group B and group A,and those in group B were higher than group A(P<0.05).Serum levels of TRACP,PINP andβ-CTX were positively correlated with the degree of bone metastases in breast cancer patients(P<0.05).Conclusion Serum levels of TRACP,PINP andβ-CTX are positively correlated with the degree of bone metastasis in breast cancer patients,and can provide valuable reference for the diagnosis of bone metastases in breast cancer patients.