新生儿生理性腹泻与母乳脂肪含量的相关性研究

Correlation Study Between Neonatal Physiological Diarrhea and Breast Milk Fat Content

目的研究新生儿生理性腹泻与母乳脂肪含量的相关性。方法选取进行分娩的健康初产妇100例为研究对象,测定产后3~5d、14d、30d的母乳脂肪含量、血脂水平[甘油三酯(TG)、胆固醇脂(TC)],并调查新生儿生理性腹泻发生情况,将发生生理性腹泻的新生儿作为观察组(n=50),未发生生理性腹泻的新生儿作为对照组(n=50),对比两组母乳脂肪含量,并分析母乳脂肪含量与血脂水平的关系。结果初乳期新生儿生理性腹泻发生率为41.00%,过渡期新生儿生理性腹泻发生率为20.00%,成熟期新生儿生理性腹泻发生率为18.00%;观察组初乳期、过渡乳期及成熟乳期母乳脂肪含量均显著高于对照组(P<0.05);观察组初乳期母体TC、TG水平均高于对照组(P<0.05),两组过渡乳期和成熟乳期母体TC、TG水平均无统计学差异(P>0.05);母乳脂肪含量与初乳期TC、TG水平呈正相关(P<0.05),与过渡乳期和成熟乳期TC、TG水平无相关性(P>0.05)。结论随母乳脂肪含量增加新生儿生理性腹泻发生率逐渐降低,且与与初乳期TC、TG水平呈正相关。

Objective To study the correlation between neonatal physiological diarrhea and breast milk fat content.Methods 100 healthy primiparas who were delivered were selected as subjects.The fat content and blood lipid level(TG,TC)of breast milk were measured at 3~5d,14d and 30d after delivery.Investigate the occurrence of neonatal physiological diarrhea.Neonates with physiological diarrhea were seen as observation group(n=50),and neonates without physiological diarrhea were seen as control group(n=50).Compare the fat content of breast milk in the two groups and analyze the relationship between breast fat content and blood lipid level.Results The incidence of physiological diarrhea in foremilk stage neonates was 41.00%,the incidence of physiological diarrhea in transitional period neonates was 20.00%,and the incidence of physiological diarrhea in mature neonates was 18.00%.The breast milk fat content in the foremilk stage,transitional period and mature lactation of the observation group was significantly higher than that of the control group(P<0.05).There was no significant difference in maternal TC and TG levels between the transitional and mature lactation(P>0.05).There was no correlation between TC and TG levels in the transitional and mature lactation periods(P>0.05).Conclusion The incidence of physiological diarrhea in neonates is gradually decreased with the increase of breast milk fat content,and it is positively correlated with TC and TG levels in colostrum.