探讨乙酰半胱氨酸联合氨溴索治疗老年慢性阻塞性肺疾病急性发作期的临床价值

To Explore the Clinical Value of Acetylcysteine Combined with Ambroxol in the Treatment of Acute Episode of Chronic Obstructive Pulmonary Disease in the Elderly

目的研究乙酰半胱氨酸联合氨溴索治疗老年慢性阻塞性肺疾病急性发作期的临床价值。方法筛选出56例患者随机分为两组。单一组28例给予氨溴索治疗,联合组28例联合乙酰半胱氨酸治疗。比较两组治疗效果。结果联合组治疗有效率为96.43%,单一组为82.14%,与单一组比较,联合组更高(P<0.05)。联合组患者三项临床症状缓解时间都比单一组早(P<0.05)。联合组患者咳嗽频率低于单一组(P<0.05),痰液粘稠度I度和III度的比例高于单一组(P<0.05);两组II度比例比较无统计学差异(P<0.05)。结论老年慢性阻塞性肺疾病急性发作期采用乙酰半胱氨酸联合氨溴索治疗,可以缓解患者呼吸困难等临床症状。

Objective To study the clinical value of acetylcysteine combined with ambroxol in the treatment of acute attack of senile chronic obstructive pulmonary disease.Methods 56 patients were randomly divided into two groups.28 cases in the single group were treated with ambroxol and 28 cases in the combined group were treated with acetylcysteine.The therapeutic effects of the two groups were compared.Results the effective rate of the combined group was 96.43%,and that of the single group was 82.14%.Compared with the single group,the combined group was higher(χ^(2)=5.333,P=0.021).The remission time of three clinical symptoms in the combined group was earlier than that in the single group(P<0.05).The cough frequency of the combined group was lower than that of the single group(P<0.05),and the proportion of sputum viscosity I and III was higher than that of the single group(P<0.05);there was no statistical difference between the two groups(P<0.05).Conclusion Acetylcysteine combined with ambroxol can relieve the dyspnea and other clinical symptoms in the elderly patients with COPD.