心宁方汤联合美托洛尔治疗室性早搏的临床研究

Clinical Study on Xinningfang Decoction Combined With Metoprolol in Treatment of Premature Ventricular Contraction

目的研究心宁丹联合美托洛尔治疗室性早搏(Premature ventricular contraction,PVC)的临床疗效。方法选取70例PVC患者,采用随机数表法将其分为研究组与对照组各35例,对照组采取美托洛尔治疗,研究组采取心宁方汤联合美托洛尔治疗,1个月为1疗程,治疗3个疗程,比较两组患者各项指标。结果研究组患者临床疗效总有效率为91.43%,对照组为71.43%,研究组总有效率显著高于对照组,差异有统计学意义(P<0.05),治疗前,两组患者心率以及发生PVC次数差异无统计学意义(P>0.05),治疗后,研究组患者心率情况较对照组患者明显变慢,发生PVC次数也明显降低,差异有统计学意义(P<0.05),研究组有4名患者产生不良反应,对照组有5名患者出现,差异无统计学意义(P>0.05)。结论采用心宁方汤联合美托洛尔治疗PVC比单纯采用美托洛尔治疗效果要好,具有一定安全性,对患者影响不大,能够有效缓解患者病情。

Objective To study clinical curative effect of Xinningdan combined with metoprolol on premature ventricular contraction(PVC).Methods A total of 70 PVC patients who were admitted to the hospital were enrolled.They were divided into study group and control group,35 cases in each group.The control group was treated with metoprolol,while study group was treated with Xinningfang Decoction combined with metoprolol.One month was defined as a course of treatment.They were treated for 3 courses.All indexes were compared between the two groups.Results The total response rate of clinical curative effect in study group was significantly higher than that in control group(91.43%vs 71.43%)(P<0.05).Before treatment,there was no significant difference in heart rate or occurrence times of PVC between the two groups(P>0.05).After treatment,heart rate of patients in study group was significantly slower than that in control group,and occurrence times of PVC was also significantly decreased(P<0.05).There were 4 cases and 5 cases with adverse reactions in study group and control group,respectively(P>0.05).Conclusion The curative effect of Xinningfang Decoction combined with metoprolol is better than that of metoprolol alone on PVC,which is of certain safety and few effect on patients.It can effectively alleviate patients'condition.