熏鲁香与乳香研究进展

Research progress of mastiche and olibanum

熏鲁香、乳香均为树脂类药材,在原植物形态、外观性状、功效等方面具有一定的相似性,以致2味药存在混用情况。结合中药相关典籍以及科学书籍数据库,对熏鲁香、乳香植物资源分布及药材性状异同进行了对比总结,对其化学成分及结构、药理作用方面的研究成果进行了较全面的分类汇总,发现两者原植物品种来源不同,化学成分存在巨大差异,其中挥发油主要成分为α-蒎烯(熏鲁香、索马里乳香)、乙酸辛酯(埃塞俄比亚乳香),树脂主要成分为五环三萜类化合物和四环三萜类化合物,且熏鲁香抗菌、抗氧化作用显著,乳香抗癌、抗炎活性较强,而药理活性主要归因于挥发油和树脂酸成分。并对2味药材质量控制现状以及不同领域应用情况进行分析,目前质量控制指标主要集中在挥发油含量及定性分析方面,对有效成分定量分析的研究较少,并且两者应用存在不同侧重,为其进一步研究和开发利用提供科学依据。

Both mastiche and olibanum are resin-based medicinal materials, which have certain similarities in the original plant morphology, appearance traits and efficacy, so that the two flavors are mixed. This study combined the Chinese herbal medicine-related classics and scientific books database to compare and summarize the distribution of the resources of the mastiche and olibanum plants and the similarities and differences of the medicinal materials. The research results of its chemical composition, structures, and pharmacological effects were comprehensively summarized. It was found that the origin of the two original plant varieties is different, and the chemical composition is greatly different. The main components of the volatile oil are α-pinene(mastiche, Somali olibanum), octyl acetate(Ethiopia olibanum), and the main components of the resin are pentacyclic triterpenes and tetracyclic triterpenes, and mastiche has significant antibacterial and antioxidative effects, and olibanum has strong anti-cancer and anti-inflammatory activities, and its pharmacological activity is mainly due to volatile oil and resin acid components. And the quality control status of the two flavor medicinal materials and the application in different fields were analyzed. At present, the quality control methods mainly focus on the volatile oil content and qualitative analysis, while the quantitative analysis of active components is less studied, and two applications has different focuses. This study will provide scientific basis for further research development and utilization of mastiche and olibanum.