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大肠癌组织中PGAM1和mTOR的表达及其临床意义

Expression of PGAM1 and mTOR in colorectal cancer and its clinical significance
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摘要 目的探讨磷酸甘油酸变位酶1(PGAM1)和雷帕霉素靶蛋白(mTOR)在大肠癌组织中的表达及其临床意义。方法选取2015年1月至2018年12月临海市第一人民医院手术切除的60例大肠癌标本,采用免疫组化En Vision法检测大肠癌组织和癌旁组织(距肿瘤原发灶>5 cm)中PGAM1和mTOR的表达情况,采用χ2检验分析PGAM1和mTOR表达与大肠癌临床病理特征的关系,Spearman秩相关分析PGAM1和mTOR表达的相关性。结果大肠癌组织中PGAM1和mTOR的阳性表达率分别为61.67%和65.00%,均明显高于癌旁组织的11.57%和10.00%,差异均有统计学意义(均P<0.05)。PGAM1、mTOR阳性表达均与大肠癌浸润深度、淋巴结是否转移、TNM分期有关(均P<0.05)。PGAM1和mTOR在大肠癌组织中的表达呈正相关(P<0.05)。结论PGAM1和mTOR表达升高可能与大肠癌的发生、发展密切相关。 Objective To investigate the expression of Phosphoglycerate mutase 1(PGAM1)and mammalian target of rapamycin(mTOR)in colorectal cancer and its clinical significance.Methods The expression of PGAM1 and mTOR in 60 cases of colorectal cancer and its adjacent tissues(more than 5cm from the primary tumor)was detected by immunohistochemistry EnVision.The relationship of PGAM1 and mTOR expression with clinicopathological characteristics of colorectal cancer was analyzed by Spearman rank correlation analysis.Results The positive rate of PGAM1 and mTOR protein in colorectal cancer tissues was higher than that in para-carcinoma colorectal tissues(61.67%vs.11.57%and 65.00%vs.10.00%,all P<0.05).The expressions of PGAM1 and mTOR were correlated with clinical stage,infiltration depth and lymph node metastasis(all P<0.05).The expression of PGAM1 was correlated with expression of mTOR in colorectal cancer(P<0.05).Conclusion The overexpression of PGAM1 and mTOR may be closely related to the occurrence and development of colorectal cancer.
作者 杨永志 陈炜 YANG Yongzhi;CHEN Wei(Department of Oncological Surgery,The First People'Hospital of Linhai,Linhai 317000,China)
出处 《浙江医学》 CAS 2021年第6期597-599,616,I0004,共5页 Zhejiang Medical Journal
基金 浙江省医药卫生科技计划项目(2020ZH078)。
关键词 大肠癌 磷酸甘油酸变位酶1 雷帕霉素靶蛋白 发生 发展 Colorectal cancer PGAM1 mTOR Occurrence Development
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