摘要
阿尔茨海默病(AD)是一种起病隐匿并且呈现进行性发展的中枢神经系统退行性疾病。近年研究发现,肠道微生态的紊乱与AD发生发展关系密切,调节肠道微生态对AD症状具有较好的改善作用,肠道菌群有望成为治疗干预AD的目标之一。部分中药复方已被实证具有调节肠道微生态的作用,提示通过中医药调节肠道微生态可望对AD起到防治作用。同时,大量文献研究表明肠道微生态的紊乱与人体脾胃功能密切相关,从脾胃调节肠道菌群,可能影响AD发病机制的形成,进而防治AD。参考文献38篇。
Alzheimer’s disease(AD)is a degenerative disease of the central nervous system with insidious onset and progressive development.Recent studies have found that the disorder of the intestinal microecology is closely related to the occurrence and development of AD.Regulating the intestinal microecology has a better effect on improving the symptoms of AD,and the intestinal flora is expected to become one of the goals of treatment and intervention in AD.Some traditional Chinese medicine(TCM)formulas have been proved to have the effect of regulating the intestinal microecology,suggesting that the regulation of intestinal microecology through TCM could play a role in preventing and treating AD.Besides,many literatures have shown that the disorder of the intestinal microecology is closely related to the function of spleen and stomach.Regulating the intestinal flora from the spleen and stomach may affect the formation of the pathogenesis of AD,to prevent and treat AD.There are 38 papers cited as references.
作者
张慧欣
第五永长
周源
安泰
刘奇
ZHANG Huixin;DIWU Yongchang;ZHOU Yuan;AN Tai;LIU Qi(Shaanxi University of Chinese Medicine,Xianyang 712046,China)
出处
《山东中医杂志》
2021年第4期425-428,439,共5页
Shandong Journal of Traditional Chinese Medicine
基金
国家自然科学基金项目(编号:2074503)
陕西省自然科学基础研究计划-重大基础研究项目(编号:2017ZDJC-15)
陕西中医药大学神经退行性疾病中医药防治研究学科创新团队项目(编号:2019-QIV05)
陕西省“特支计划”科技创新领军人才项目(批文号:陕组通字[2018]33号)。
关键词
阿尔茨海默病
补益脾胃
肠道微生态
肠道菌群
中药复方
Alzheimer’s disease
tonifying spleen and stomach
intestinal microecology
intestinal flora
traditional Chinese medicine formula