血小板在脓毒症中的研究进展

Research progress of platelets in sepsis

脓毒症为感染致全身免疫失调的炎症反应综合征,血小板在脓毒症发生发展中起着重要作用。血小板可通过黏附、聚集、活化、脱颗粒作用与病原微生物相反应,以达到保护机体的作用。同时,脓毒症时血小板还可与中性粒细胞等免疫细胞相互作用,参与微血栓、炎症的形成。因此,血小板有抗微生物效应及与其他先天免疫细胞协作,形成复杂的血管内免疫防御系统,防止细菌传播的功能。但其介导的免疫功能如果失调,可致宿主细胞和组织受到严重的附带损害,导致脓毒症相关器官功能障碍。本文对血小板在脓毒症及其器官功能障碍中的免疫机制作一综述。

Sepsis is an inflammatory response syndrome caused by systemic immune disorders caused by infection.Platelets play an important role in the development of sepsis.Platelets can react with pathogenic microorganisms through adhesion,aggregation,activation,threshing,and have achieved the role of protecting in the body.At the same time,during sepsis,platelets can also interact with immune cells such as neutrophils and participate in formation of microthrombi and inflammation.Therefore,platelets have an antimicrobial effect and cooperate with other innate immune cells to form a complex intravascular immune defense system to prevent the spread of bacteria.However,if the internal immune function mediated by it is dysregulated,the host cells and tissues may be seriously collaterally damaged,resulting in sepsis-related organ dysfunction.This article reviewed the research progress of platelet immune mechanism and organ dysfunction in sepsis.