摘要
近期研究表明,2型糖尿病与骨折密切相关,是骨折发生的独立危险因素,高血糖和胰岛素相对不足可能是2型糖尿病患者骨强度下降、骨折风险提升的重要机制。本文就2型糖尿病骨折流行病学、发病机制以及降糖药物对骨折风险的影响进行综述,以期改善2型糖尿病患者的骨骼健康。
Recent studies have shown that type 2 diabetes mellitus is closely related to the fractures,which is an independent risk factor for fractures,and hyperglycemia and the relative lack of insulin in patients with type 2 diabetes mellitus may be the important mechanisms for reduction of bone strength and increase of risk of fracture.This article reviews the epidemiology,related mechanisms of type 2 diabetic fractures and the effects of antidiabetic medications on risk of fracture,so as to improve the bone health of patients with type 2 diabetes.
作者
施奕万
王华军
郑小飞
SHI Yiwan;WANG Huajun;ZHENG Xiaofei(Department of Joint and Sports Medicine,the First Clinical Medical College of Jinan University,the First Affiliated Hospital of Jinan University,Guangzhou,Guangdong 510630,China)
出处
《中国骨科临床与基础研究杂志》
2020年第5期304-311,共8页
Chinese Orthopaedic Journal of Clinical and Basic Research
基金
中国博士后科学基金资助项目(2017T100660)
广东省自然科学基金项目(2016A030313100)
广东省医学科学技术研究基金项目(A2019100,A2018544)。
关键词
糖尿病
2型
骨折
流行病学
危险因素
成骨细胞
破骨细胞
胰岛素样生长因子Ⅰ
骨密度
骨重建
降血糖药
Diabetes mellitus,type 2
Fractures
Epidemiology
Risk factors
Osteoblasts
Osteoclasts
Insulin-like growth factor Ⅰ
Bone density
Bone remodeling
Hypoglycemic agents
