基于AMPK及下游靶点的黄连素防治缺血性脑卒中的研究进展

Research Progress of the Prevention and Treatment of Ischemic Stroke by Berberine Based on AMPK and Its Downstream Targets

从近些年的研究可知,能量代谢障碍是造成缺血性脑损伤重要的始动因素,继而出现氧化应激、神经炎症、谷氨酸受体的激活、钙超载、凋亡等病理事件的发生。实验性及临床研究发现黄连素可以治疗缺血性脑卒中,其可能机制在于激活腺苷酸活化蛋白激酶及其下游靶点,包括核因子相关因子-2,核因子-κB,磷酸肌醇3-激酶/蛋白激酶B和雷帕霉素靶蛋白,从而改善氧化应激、神经炎症、谷氨酸兴奋性毒性、凋亡,促进自噬和血管生成等,为黄连素防治缺血性脑卒中的临床应用提供有力依据。

Recent studies showed that energy metabolism disorder was an important initiating factor of ischemic brain injury,which leads to oxidative stress,neuroinflammation,the activation of glutamate receptor,calcium overload,and apoptosis and other pathological events.Experimental and clinical studies have found that berberine can be used in the treatment of ischemic stroke,whose possible mechanism is to activate AMP-activated protein kinase and its downstream targets,including nuclear factor E2-related factor 2,nuclear factor-κB,phosphoinositide 3-kinase/protein kinase B and mammalian target of rapamycin,so as to improve oxidative stress,neuroinflammation,glutamate excitotoxicity,apoptosis,promote autophagy and angiogenesis,providing a strong basis for the clinical application of berberine in the prevention and treatment of ischemic stroke.