抗菌药物与洛匹那韦/利托那韦相互作用研究进展

Research Progress of Interactions Between Antibacterials and Lopinavir/Ritonavir

口服抗病毒药洛匹那韦/利托那韦的抗病毒作用受很多因素的影响,如患者性别、种族、合并症、用药依从性等。与其他药物的相互作用也是影响洛匹那韦/利托那韦抗病毒的重要因素之一,其中一些抗菌药物对洛匹那韦/利托那韦的影响较大且机制复杂,作用持续时间也较长,对于联用洛匹那韦/利托那韦合并细菌或真菌感染的患者,抗菌药物的选择与监测更为重要。本文通过综述国内外相关研究,探讨和总结洛匹那韦/利托那韦与抗菌药物的相互作用机制和应对策略,比较不同抗菌药物的药动学特性及与洛匹那韦/利托那韦相互作用的差异,从而为抗菌药物的选择和相应剂量的调整提供参考,降低患者用药风险,提高安全性。

The effectiveness of lopinavir/ritonavir,an oral antiviral drug,was affected by patient’s sex,race,presence of comorbidities,adherence.Interactions with other drugs was also one of the important factors affecting the antiviral action of lopinavir/ritonavir,the interactions among lopinavir/ritonavir and some antibacterials were major,complex and delayed.Thus,the choice of antibacterials and concentration monitoring were very important for the patient with bacterial or fungal infections receiving lopinavir/ritonavir treatment.This review summarized the data about the influence of antibacterials on lopinavir/ritonavir treatment and analyzed interaction mechanisms and suggested management to provide reference about choice of antibacterials and dosage adjustment of antibacterials,to avoid the risk of medication and improved safety.