摘要
口服抗病毒药洛匹那韦/利托那韦的抗病毒作用受很多因素的影响,如患者性别、种族、合并症、用药依从性等。与其他药物的相互作用也是影响洛匹那韦/利托那韦抗病毒的重要因素之一,其中一些抗菌药物对洛匹那韦/利托那韦的影响较大且机制复杂,作用持续时间也较长,对于联用洛匹那韦/利托那韦合并细菌或真菌感染的患者,抗菌药物的选择与监测更为重要。本文通过综述国内外相关研究,探讨和总结洛匹那韦/利托那韦与抗菌药物的相互作用机制和应对策略,比较不同抗菌药物的药动学特性及与洛匹那韦/利托那韦相互作用的差异,从而为抗菌药物的选择和相应剂量的调整提供参考,降低患者用药风险,提高安全性。
The effectiveness of lopinavir/ritonavir,an oral antiviral drug,was affected by patient’s sex,race,presence of comorbidities,adherence.Interactions with other drugs was also one of the important factors affecting the antiviral action of lopinavir/ritonavir,the interactions among lopinavir/ritonavir and some antibacterials were major,complex and delayed.Thus,the choice of antibacterials and concentration monitoring were very important for the patient with bacterial or fungal infections receiving lopinavir/ritonavir treatment.This review summarized the data about the influence of antibacterials on lopinavir/ritonavir treatment and analyzed interaction mechanisms and suggested management to provide reference about choice of antibacterials and dosage adjustment of antibacterials,to avoid the risk of medication and improved safety.
作者
张若英
徐颖颖
郑韧
王怀冲
王宇
蔡鑫君
ZHANG Ruoying;XU Yingying;ZHENG Ren;WANG Huaichong;WANG Yu;CAI Xinjun(Department of Pharmacy,Zhejiang Integrated Traditional and Western Medicine Hospital,Hangzhou 310003,China)
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2021年第4期503-507,共5页
Chinese Journal of Modern Applied Pharmacy
基金
浙江省药学会医院药学专项科研资助项目(2019ZYY27)
杭州市医坛新秀培养对象(2020年度)。