益气凉血生肌方对PCI术后中医症状及证候要素影响的研究

Effects of Yiqi Liangxue Shengji Prescription on TCM Symptoms and Syndrome Elements after PCI

目的评价益气凉血生肌方对经皮冠状动脉介入治疗(PCI)术后患者主要症状及中医证候要素的影响。方法选取2015年10月—2017年1月成功行PCI的患者,采用随机对照原则,分为对照组46例,治疗组42例。两组均采用《中国经皮冠状动脉介入治疗指南》推荐的介入术后常规西药治疗,包括抗血小板药物、他汀类药物、血管紧张素转化酶抑制剂(ACEI)或血管紧张素Ⅱ受体拮抗剂(ARB)类药物等。治疗组在常规西药治疗基础上加服益气凉血生肌方颗粒,疗程8周。评价治疗前后两组患者中医症状体征积分及中医证候要素改善情况。结果治疗8周后,两组中医症状、体征积分均较本组治疗前降低(P<0.05),差异具有统计学意义;治疗组治疗后胸闷、气短、乏力积分低于对照组(P<0.05),差异有统计学意义。治疗组中医症状体征改善明显优于对照组(P<0.05),差异有统计学意义。治疗组血瘀、热蕴、痰浊、气虚证候要素较本组治疗前明显改善(P<0.05),差异有统计学意义;对照组血瘀、热蕴、气虚证候要素较本组治疗前明显改善(P<0.05),差异有统计学意义;治疗组治疗后血瘀、热蕴、气虚证候要素改善明显优于对照组(P<0.05),差异有统计学意义。结论在常规西药治疗基础上加用益气凉血生肌方可明显改善PCI术后患者胸闷、气短、乏力症状,改善气虚、血瘀、热蕴证候。

Objective To evaluate the efficacy of Yiqi Liangxue Shengji prescription on Traditional Chinese Medicine(TCM)symptoms and syndrome elements in patients after PCI.Methods Selected patients who successfully underwent PCI from October 2015 to January 2017,using the principle of randomized control,divided into a control group of 46 cases and a treatment group of 42 cases.Both groups were treated with conventional western medicines after intervention recommended by the guidelines,including antiplatelet drugs,statins,angiotensin converting enzyme inhibitors(ACEI)or angiotensin II receptor antagonists(ARB)drugs.The traditional Chinese medicine treatment group was treated with Yiqi Liangxue Shengji prescription on the basis of conventional Western medicine treatment for 8 weeks.The improvement of the TCM symptom scores and TCM syndrome elements of the two groups of patients were evaluated before and after treatment.Results After 8 weeks of treatment,the scores of TCM symptoms and signs of the two groups were lower than those of the group before treatment(P<0.05),and the difference was statistically significant;the scores of chest tightness,shortness of breath,and fatigue after treatment in the treatment group were lower than those of the control group,and there were differences Statistically significant(P<0.05).The improvement of TCM symptoms and signs in the treatment group was significantly better than that in the control group(P<0.05),and the difference in overall efficacy between the two groups was statistically significant.The blood stasis,heat accumulation,phlegm turbidity,and qi deficiency syndrome elements in the treatment group were significantly improved compared with those before treatment(P<0.05),and the difference was statistically significant;the blood stasis,heat accumulation,and qi deficiency syndrome elements in the confrol group were significantly improved than before treatment(P<0.05),the difference was statistically significant;the improvement of blood stasis,heat accumulation and qi deficiency in the treatment group was significantly better than that of the control group(P<0.05),and the difference was statistically significant.Conclusion On the basis of routine western medicine treatment,Yiqi Liangxue Shengji prescription can obviously improve the symptoms of chest tightness,shortness of breath and fatigue,and improve the syndromes of qi deficiency,blood stasis and heat accumulation in patients after PCI.