ACTL6A在宫颈癌中的表达及意义

Expression and significance of ACTL6A in cervical cancer

目的:探讨ACTL6A在宫颈癌中的表达及意义。方法:收集2012年1月至2015年1月间我院收治的93例宫颈癌患者的癌组织和癌旁组织石蜡标本,采用免疫组化法测定ACTL6A表达情况,分析其与临床病理参数及预后之间的关系。应用多因素Cox回归分析预测不良事件的指标。结果:ACTL6A在宫颈癌癌组织阳性表达率(63.5%)明显高于癌旁组织(27.9%)(P<0.05)。ACTL6A蛋白高表达与宫颈癌的淋巴结转移、组织学分解、TNM分期相关,而与患者年龄、肿瘤大小无关。随访时间3-60个月,宫颈癌癌组织高表达ACTL6A蛋白的患者总生存明显低于低表达的患者(P<0.05);其中淋巴结转移、组织学分级、TNM分期和ACTL6A均是宫颈癌患者预后的独立影响指标。结论:ACTL6A与宫颈癌的发生和进展关系密切,是判断宫颈癌患者预后的重要指标。

Objective:To explore the expression and significance of ACTL6A in cervical cancer.Methods:From January 2012 to January 2015,93 paraffin specimens of cancer tissues and adjacent tissues of patients with cervical cancer were collected.Immunohistochemical method was used to determine the expression of ACTL6A,and its relationship with clinical pathological parameters and prognosis was analyzed.Multi-factor Cox regression analysis was an indicator for predicting adverse events.Results:The positive expression rate of ACTL6A in cervical cancer tissues(63.5%)was significantly higher than that in adjacent tissues(27.9%)(P<0.05).The high expression of ACTL6A protein is associated with lymph node metastasis,histological decomposition,and TNM staging of cervical cancer,but has nothing to do with the patient's age and tumor size.Follow-up time was 3-60 months.In cervical cancer tissues,patients with high expression of ACTL6A protein had poorer overall survival,compared with patients with low expression(P<0.05).Among them,lymph node metastasis,histological grading,TNM staging and ACTL6A were all independent indicators of the prognosis of cervical cancer patients.Conclusion:ACTL6A is closely related to the occurrence and progression of cervical cancer,and is an important indicator to judge the prognosis of cervical cancer patients.