一碳代谢与肿瘤治疗的研究进展

Progress in One-carbon Metabolism and Tumor Therapy

近年来,“肿瘤是一种代谢性疾病”已经成为共识,肿瘤的代谢重编程成为了当下研究的热点。一碳代谢包含了叶酸循环、蛋氨酸循环和转硫化途径。一碳单位可通过这三个途径产生和利用嘧啶、胸苷酸、S-腺苷蛋氨酸、谷胱甘肽等来调节肿瘤的生长和增殖。本文主要阐述肿瘤中一碳单位的产生与利用以及一碳代谢与肿瘤发生发展的相互作用,为一碳代谢在肿瘤发生中的机制研究以及肿瘤的营养素等治疗提供新思路。

In recent years,it has already run into a common view that“tumor is a metabolic disease”,and the reprogramming of tumor metabolism has become the focus of current research.One-carbon metabolism involves folate cycle,methionine cycle and trans-sulfuration pathway.By utilizing these three ways,one carbon unit can regulate tumor growth and proliferation with the production of pyrimidine,thymidine,s-adenosine,glutathione,etc.This paper mainly describes the production and utilization of one carbon unit in tumor,as well as the interaction between one carbon metabolism and tumor development,providing new ideas for studying the mechanism of one-carbon metabolism in tumorigenesis and the treatment of nutrients in tumor.