膀胱癌靶向分子载体的研究进展

Research Progress of Targeted Molecular Carrier for Bladder Cancer

膀胱癌(BC)是泌尿系统常见的恶性肿瘤。普通白光膀胱镜检查是BC诊疗最重要的手段,但其对微小肿瘤、手术部位残留肿瘤的识别能力有限,迫切需要研发新的诊疗技术。随着精准医学概念的兴起,近年来发现了一批能够在细胞和分子水平与BC特异性结合的靶向分子,以其为载体进行的分子影像诊断和靶向治疗能显著提高肿瘤的诊疗效率,具有巨大的临床应用潜力。本文结合国内外最新研究进展及本研究组的工作,对靶向分子载体在BC诊疗过程中的应用进行综合分析和系统综述。

Bladder cancer(BC)is a common malignant tumor of the urinary system.Common white light cystoscopy is the most important method in the diagnosis and treatment of BC,but its ability to identify small tumors and residual tumors at surgical sites is limited,so it is urgent to develop new diagnosis and treatment techniques.With the rise of the concept of precision medicine,a group of targeted molecules that can specifically bind to BC at the cellular and molecular levels have been discovered in recent years,and the molecular image and targeted therapy based on them can significantly improve the diagnosis and treatment efficiency of BC,with a great potential for clinical application.Based on the latest progress and the research work of our research group,this paper comprehensively analyzes and systematically summarizes the application of targeted molecular carriers in the diagnosis and treatment of BC.