摘要
骨肉瘤(OS)是临床最常见的原发恶性骨肿瘤,其病死、病残率高,有效的新辅助化疗联合保肢手术可提高OS患者的5年生存率,肿瘤细胞耐药或低敏感度是导致术后局部复发与转移最常见的原因,因此,OS细胞对化疗药物的敏感度对患者的预后有重要价值。近年来,中药因其高效、低毒的优势,在肿瘤的应用中日益广泛,已有大量研究证实部分中药可通过调控ABC跨膜转运蛋白系统逆转OS细胞的化疗耐药,本文就其相关机制及最新进展作一概述。
Osteosarcoma(OS)is the most common primary malignant bone tumor in clinic.It has high mortality and disability rate.Effective neoadjuvant chemotherapy combined with limb salvage surgery can improve the 5-year survival rate of OS patients.Drug resistance or low sensitivity of tumor cells is the most common cause of postoperative local recurrence and metastasis.Therefore,the sensitivity of OS cells to chemotherapy drugs is of great value to the prognosis of the patients.In recent years,traditional Chinese medicine has been widely used because of high efficiency and low toxicity.A large number of studies have confirmed that part of traditional Chinese medicine can reverse the chemotherapy resistance of OS cells by regulating the ABC transmembrane transport protein system.This article gives an overview of its related mechanisms and latest developments.
作者
丁聚贤
谢兴文
许伟
李鼎鹏
李宁
苏积亮
柳博
李建国
柴利军
DING Juxian;XIE Xingwen;XU Wei;LI Dingpeng;LI Ning;SU Jiliang;LIU Bo;LI Jianguo;CHAI Lijun(Department of Orthopedics,Affiliated Hospital of Northwest Minzu University,Lanzhou 730000,China;Graduate School of Gansu University of Chinese Medicine,Lanzhou 730000,China;Department of Bone Oncology,Gansu Provincial Hospital of TCM,Lanzhou 730050,China)
出处
《肿瘤防治研究》
CAS
CSCD
2021年第3期303-306,共4页
Cancer Research on Prevention and Treatment
基金
国家自然科学基金(81704104)
甘肃省青年科技基金(17JR5RA050)。
关键词
骨肉瘤
化疗耐药
中医药
ABC跨膜蛋白
Osteosarcoma
Chemotherapy resistance
TCM
ABC transmembrane protein