中医药通过调控ABC跨膜转运蛋白逆转骨肉瘤化疗耐药的研究进展

Reviews on TCM in Reversing Chemotherapy Resistance of Osteosarcoma from ABC Transmembrane Protein

骨肉瘤(OS)是临床最常见的原发恶性骨肿瘤,其病死、病残率高,有效的新辅助化疗联合保肢手术可提高OS患者的5年生存率,肿瘤细胞耐药或低敏感度是导致术后局部复发与转移最常见的原因,因此,OS细胞对化疗药物的敏感度对患者的预后有重要价值。近年来,中药因其高效、低毒的优势,在肿瘤的应用中日益广泛,已有大量研究证实部分中药可通过调控ABC跨膜转运蛋白系统逆转OS细胞的化疗耐药,本文就其相关机制及最新进展作一概述。

Osteosarcoma(OS)is the most common primary malignant bone tumor in clinic.It has high mortality and disability rate.Effective neoadjuvant chemotherapy combined with limb salvage surgery can improve the 5-year survival rate of OS patients.Drug resistance or low sensitivity of tumor cells is the most common cause of postoperative local recurrence and metastasis.Therefore,the sensitivity of OS cells to chemotherapy drugs is of great value to the prognosis of the patients.In recent years,traditional Chinese medicine has been widely used because of high efficiency and low toxicity.A large number of studies have confirmed that part of traditional Chinese medicine can reverse the chemotherapy resistance of OS cells by regulating the ABC transmembrane transport protein system.This article gives an overview of its related mechanisms and latest developments.