温肺通窍方对儿童肺气虚寒型过敏性鼻炎黏膜免疫影响的临床研究

Clinical Study on the Effect of Wenfei Tongqiao Prescription on Mucosal Immunity in Children with Lung Qi Deficiency-cold Type of Allergic Rhinitis

【目的】通过观察温肺通窍方治疗肺气虚寒型过敏性鼻炎患儿的临床疗效,探索温肺通窍方对此类患儿局部慢性炎症及黏膜免疫的影响。【方法】将84例肺气虚寒型过敏性鼻炎患儿随机分为试验组和对照组,每组各42例。试验组给予温肺通窍方治疗,对照组给予氯雷他定片治疗,疗程为7 d。观察2组患儿治疗前后鼻呼气一氧化氮(FeNO)浓度和鼻腔盥洗液分泌型免疫球蛋白A(sIgA)浓度的变化情况,评价2组患儿的中医证候疗效。【结果】(1)研究过程中,试验组有2例脱落,对照组有4例脱落。实际完成试验有78例,其中试验组40例,对照组38例。(2)治疗7 d后,试验组的总有效率为95.0%(38/40),对照组为76.3%(29/38),试验组的中医证候疗效明显优于对照组,差异有统计学意义(P<0.05)。(3)治疗后,2组患儿FeNO浓度均较治疗前明显下降(P<0.01),且试验组对FeNO浓度的下降作用明显优于对照组,差异有统计学意义(P<0.05)。(4)治疗后,2组患儿sIgA浓度均较治疗前明显升高(P<0.01),且试验组对sIgA浓度的升高作用明显优于对照组,差异有统计学意义(P<0.01)。【结论】温肺通窍方治疗肺气虚寒型过敏性鼻炎疗效确切,可有效改善患儿的临床症状和鼻部慢性炎症,提高患儿鼻部黏膜的免疫功能。

Objective To investigate the clinical efficacy of Wenfei Tongqiao Prescription for the treatment of children with lung qi deficiency-cold type of allergic rhinitis and to observe its effect on local chronic inflammation and mucosal immunity of the children with lung qi deficiency-cold type of allergic rhinitis.Methods A total of 84 children with lung qi deficiency-cold type of allergic rhinitis were randomly divided into trial group and control group,with 42 cases in each group.The trial group was treated with Wenfei Tongqiao Prescription,and the control group was treated with Loratadine Tablets.The two groups were treated for 7 days.Before and after treatment,fractional exhaled nitric oxide(FeNO)concentration and secretory immunoglobulin A(sIgA)concentration in the nasal lavage fluid of the two groups were measured,and the efficacy for traditional Chinese medicine(TCM)syndrome was also evaluated after treatment.Results(1)During the trial,2 cases from the trial group and 4 cases from the control group dropped out,and a total of 78 cases(40 cases from the trial group and 38 cases from the control group)completed the trial.(2)After treatment for 7 days,the total effective rate of the trial group was 95.0%(38/40),and that of the control group was 76.3%(29/38).The intergroup comparison showed that the clinical efficacy of the trial group was superior to that of the control group,and the difference was statistically significant(P<0.05).(3)After treatment,FeNO concentration in the two groups was decreased in comparison with that before treatment(P<0.01),and the decrease of FeNO in the trial group was superior to that in the control group,the difference being statistically significant(P<0.05).(4)After treatment,sIgA concentration in the two groups was increased in comparison with that before treatment(P<0.01),and the increase of sIgA in the trial group was superior to that in the control group,the difference being statistically significant(P<0.01).Conclusion Wenfei Tongqiao Prescription exerts certain effect for the treatment of children with lung qi deficiencycold type of allergic rhinitis by significantly relieving the clinical symptoms and chronic nasal inflammation and by improving the mucosal immune function of children with allergic rhinitis.