腰椎间盘退变动物模型研究进展及其“筋骨并重”复合因素实验动物模型构建思路

Research Progress of Animal Model of Lumbar Intervertebral Disc Degeneration and Construction of Complicated Lumbar Intervertebral Disc Degeneration Animal Model Based on“Paying Equal Attention to Sinew and Bones”

通过分析目前应用较广泛的几种腰椎间盘退变动物模型的建模方法及特点,从“筋骨并重”理论探讨构建具有中医理论特色的腰椎间盘退变复合因素实验动物模型。目前腰椎间盘退变动物模型主要包括机械损伤模型、应力改变模型、敲除特定基因模型、自发性椎间盘退变模型以及其他模型等。上述动物模型虽然被广泛应用,但仍存在各种不足,较难全面模拟临床实际症状。为进一步探索中医药疗法对腰椎间盘退变的治疗作用机制,提出从“筋骨并重”理论出发,结合腰椎间盘退变风险因素诱导建立有效的腰椎间盘退变复合因素实验动物模型。

By analyzing the modeling methods and characteristic features of several widely-used animal models of lumbar intervertebral disc degeneration,we discussed the construction of the complex-factor induced animal model of lumbar intervertebral disc degeneration based on the traditional Chinese medicine theory of“paying equal attention to sinew and bones”.Till now,the animal models of lumbar disc degeneration mainly include mechanical injury model,stress-change induced model,specific gene knockout model,spontaneous disc degeneration model and other models.Although the above animal models are widely used,various deficiencies still exist in the present animal model of lumbar intervertebral disc degeneration for they fail in copying the actual clinical symptoms.In order to further explore the therapeutic mechanism of Chinese medicine therapy for the degeneration of intervertebral disc,we explored the feasibility of establishing the complex-factor induced animal model of lumbar intervertebral disc degeneration based on the traditional Chinese medicine theory of“paying equal attention to sinew and bones”and by combining with the risk factors of lumbar intervertebral disc degeneration.