血清miR-103水平与抑郁症患者胰岛素抵抗的相关性

Study on the correlation between serum miR-103 level and insulin resistance in patients with depression

目的分析血清微小RNA-103水平与抑郁症患者胰岛素抵抗的相关性。方法将96例抑郁症合并胰岛素抵抗患者设为研究组,50名健康者设为对照组。比较两组患者的抑郁严重指数、空腹血糖、糖化血红蛋白、空腹胰岛素、皮质醇及胰岛素抵抗指数,检测血清微小RNA-103表达水平。分析血清微小RNA-103水平与抑郁严重指数、胰岛素抵抗指数、皮质醇水平的相关性,并对胰岛素抵抗的相关因素进行多元逐步回归分析。结果研究组抑郁严重指数、空腹胰岛素、皮质醇、胰岛素抵抗指数及血清微小RNA-103水平显著高于对照组(P<0.01)。治疗后研究组抑郁严重指数、空腹胰岛素、皮质醇、胰岛素抵抗指数及血清微小RNA-103水平均显著低于治疗前(P<0.05或0.01)。血清微小RNA-103水平与抑郁严重指数、胰岛素抵抗指数及皮质醇水平均呈显著正相关(P<0.01)。血清微小RNA-103、抑郁严重指数及皮质醇水平是患者胰岛素抵抗指数的影响因素。结论血清微小RNA-103水平与抑郁症合并胰岛素抵抗患者的抑郁严重程度、胰岛素抵抗指数及皮质醇水平呈显著正相关,具有评估抑郁症合并胰岛素抵抗患者病情严重程度的应用价值。

Objective To analyze the correlation between serum microRNA-103(miR-103)level and insulin resistance(IR)in patients with depression.Methods The 96 patients with depression and IR were set as the study group,and 50 healthy people were set as the control group.The depression severity index,fasting plasma glucose(FPG),glycosylated hemoglobin(HbA1c),fasting plasma insulin(FINS),cortisol and HOMA-IR were compared between the two groups of patients,and serum miR-103 levels were detected.Analyze the correlation between serum miR-103 level and depression severity index,HOMA-IR,cortisol level.The related factors of IR were analyzed by multiple stepwise regression.Results The levels of depression severity index,FINS,cortisol,HOMA-IR and serum miR-103 in the study group were significantly higher than those in the control group(P<0.01).After treatment,the depression severity index,FINS,cortisol,OME-IR and serum miR-103 levels in the study group were significantly lower than before treatment(P<0.05 or 0.01).Serum miR-103 levels were significantly positively correlated with depression severity index,HOMA-IR and cortisol levels(P<0.01).Serum miR-103,depression severity index and cortisol level was an factor influencing the patient's insulin resistance index.Conclusions Serum miR-103 level is significantly positively correlated with the severity of depression,HOMA-IR and cortisol in patients with depression and IR,and has application value in evaluating the severity of patients with depression and IR.