序贯肠内外营养支持对慢性阻塞性肺疾病急性加重期合并呼吸衰竭患者的影响

Effect of sequential enteral and parenteral nutrition for patients with acute exacerbation of chronic obstructive pulmonary disease complicated with respiratory failure

目的探讨序贯肠内外营养支持对慢性阻塞性肺疾病急性加重期(AECOPD)合并呼吸衰竭患者营养状况及预后的影响。方法将60例AECOPD合并呼吸衰竭患者随机分为对照组和观察组,每组30例。对照组给予肠内营养支持,观察组采用序贯肠内外营养支持。比较2组营养状况、康复指标及并发症发生率。结果营养支持1周后,观察组血清白蛋白(ALB)、转铁蛋白(TRF)、前白蛋白(PA)高于对照组,机械通气时间、ICU住院时间短于对照组,差异有统计学意义(P<0.05)。观察组并发症发生率为3.33%,低于对照组的26.67%,差异有统计学意义(P<0.05)。结论序贯肠内外营养支持可改善AECOPD合并呼吸衰竭患者营养状况,减少其并发症,加快康复进程。

Objective To investigate the effect of sequential enteral and parenteral nutrition on nutritional status and prognosis of patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)complicated with respiratory failure.Methods A total of 60 patients with AECOPD complicated with respiratory failure were randomly divided into control group and observation group,with 30 cases in each group.The control group received enteral nutrition support,and the observation group received sequential enteral and parenteral nutrition support.The nutritional status,rehabilitation index and complication rate of the two groups were compared.Results After one week of nutritional support,serum albumin(ALB),transferrin(TRF)and prealbumin(PA)in the observation group were significantly higher than those in the control group,and mechanical ventilation duration as well as length of ICU stay were significantly shorter than those in the control group(P<0.05).The complication rate in the observation group was 3.33%,which significantly lower than 26.67%in the control group(P<0.05).Conclusion Sequential parenteral and parenteral nutritional support can improve the nutritional status of patients with AECOPD complicated with respiratory failure,reduce their complications and speed up the recovery process.