右美托咪定在小儿纤维支气管镜检查和肺泡灌洗中的应用

Application of dexmedetomidine for children undergoing fiberbronchoscope and bronchoalveolar lavage

目的探讨右美托咪定应用于小儿纤维支气管镜检查和肺泡灌洗术的效果。方法将行纤维支气管镜检查和肺泡灌洗术的54例患儿随机分为右美托咪定组(Dex组)和对照组,每组27例。2组均采用全身麻醉,Dex组术前给予右美托咪定,对照组按相同方法给予生理盐水。观察2组生命体征变化,比较2组肿瘤坏死因子-α(TNF-α)、总蛋白含量和白细胞介素-1β(IL-1β)的水平变化。结果Dex组血清TNF-α、肺泡灌洗液中总蛋白含量水平均低于对照组,差异有统计学意义(P<0.05)。Dex组肺泡灌洗液中(BALF)TNF-α和IL-1β水平均低于对照组,差异有统计学意义(P<0.05)。结论右美托咪定应用于小儿纤维支气管镜和肺泡灌洗术,可减少肺部炎症反应,发挥肺保护作用。

Objective To investigate the effect of dexmedetomidine for children undergoing fiberbronchoscope and bronchoalveolar lavage.Methods A total of 54 children undergoing fiberbronchoscopy and a bronchoalveolar lavage were randomly divided into dexmedetomidine group(Dex group)and control group,with 27cases in each group.Both groups were given general anesthesia,Dex group was given dexmedetomidine before surgery,and control group was given normal saline according to the same method.The vital signs were observed and the levels of tumor necrosis factor-α(TNF-α),total protein and interleukin-1β(IL-1β)were compared in the two groups.Results The serum TNF-αand total protein levels in the Dex group were significantly lower than those in the control group(P<0.05).The TNF-αand IL-1βlevels in bronchoalveolar lavage fluid(BALF)in the Dex group were significantly lower than those in the control group(P<0.05).Conclusion Dexmedetomidine can reduce lung inflammation and plays a protective role in the lungs of children undergoing fiberbronchoscopic examination and bronchoalveolar lavage.