门冬氨酸鸟氨酸联合乳果糖治疗肝硬化伴肝性脑病患者的临床效果

Clinical Effect of Ornithine Aspartate Combined with Lactulose in the Treatment of Cirrhosis with Hepatic Encephalopathy

目的系统性评价门冬氨酸鸟氨酸联合乳果糖治疗肝硬化伴肝性脑病患者的临床效果。方法选取2018年3月至2019年3月于大连友谊医院重症二病房住院接受治疗的60例肝硬化伴肝性脑病患者,将入组病例采用信封法随机分为对照组和试验组,每组30例。对照组应用乳果糖治疗,试验组在对照组基础上联合门冬氨酸鸟氨酸治疗,观察两组患者治疗前后的转氨酶、血氨浓度及数字连接试验-A(NCT-A)时间变化情况。结果治疗后,试验组ALT、AST、血氨浓度、NCT-A时间均优于对照组(P<0.05)。结论门冬氨酸鸟氨酸联合乳果糖治疗方案可有效改善肝硬化伴肝性脑病患者的肠道内环境,阻断外源性毒性氨的合成及吸收,降低血氨浓度,促进肝功能的恢复,同时可有效减轻肝性脑病及脑水肿状态,改善患者的神经功能。

Objective To systematically evaluate the clinical effect of ornithine aspartate combined with lactulose in the treatment of liver cirrhosis with hepatic encephalopathy.Methods From March 2018 to March 2019,60 patients with liver cirrhosis and hepatic encephalopathy in the second intensive care unit of Dalian Friendship Hospital were selected and randomly divided into control group and experimental group by envelope method,30 cases in each group.The control group was treated with lactulose,and the experimental group was treated with ornithine aspartate on the basis of the control group.The changes of transaminase,blood ammonia concentration and NCT-A time before and after treatment were observed.Results After treatment,the test group’s ALT,AST,blood ammonia concentration,and NCT-A time are better than those of the control group(P<0.05).Conclusion Ornithine aspartate combined with lactulose can effectively improve the intestinal environment of patients with liver cirrhosis complicated with hepatic encephalopathy,block the synthesis and absorption of exogenous toxic ammonia,reduce the concentration of blood ammonia,promote the recovery of liver function,effectively reduce the state of hepatic encephalopathy and brain edema,and improve the neurological function of patients.