摘要
鸟巢烷型二萜是大型真菌来源二萜化合物中最大的类群,其化学结构特征是包含5/6/7元环杂合的三环骨架。由于鸟巢烷型二萜具有以刺激神经生长因子合成为代表的多种生物活性,其人工合成和相关药物开发引起了广泛关注。总结近年来报道的来源于黑蛋巢菌属(Cyathus)、猴头菌属(Hericium)和肉齿菌属(Sarcodon)等大型真菌的多种鸟巢烷型二萜的化学结构和生物活性,介绍其化学合成和生物合成方面的研究进展。
Cyathanes with 5/6/7 ring-fused diterpenes are the largest group of diterpenoids from macrofungi.Due to their rich biological activities,especially the nerve growth factor-inducing activity,cyathanes have attracted considerable attentions in terms of drug discovery and compound synthesis.This review compiled research progress on chemical structure and biological activity of cyathanes from Cyathus,Hericium and Sarcodon.Progress on both chemical synthesis and biosynthesis of cyathanes were also reviewed so as to provide a reference for research and development of natural products from macrofungi in the future.
作者
彭勤颖
邹根
高利慧
白林泉
TAN Yeeshin
吴莹莹
PENG Qinying;ZOU Gen;GAO Lihui;BAI Linquan;TAN Yeeshin;WU Yingying(Institute of Edible Fungi,Shanghai Academy of Agricultural Sciences,National Engineering Research Center of Edible Fungi,Key Laboratory of Applied Mycological Resources and Utilization(South),Ministry of Agriculture and Rural Affairs,P.R.China,Shanghai 201403,China;State Key Laboratory of Microbial Metabolism,School of Life Sciences&Biotechnology,Shanghai Jiao Tong University,Shanghai 200240,China;Institute of Biological Sciences,Faculty of Science&Mushroom Research Centre,University Malaya,Kuala Lumpur 50603,Malaysia)
出处
《食用菌学报》
CSCD
北大核心
2021年第2期140-154,共15页
Acta Edulis Fungi
基金
上海市闵行区“领军人才”培养计划(201947)
上海市科委国际科技合作基金项目(18390741000)。
关键词
鸟巢菌
化学结构
生物活性
化学合成
生物合成
二萜环化酶
Bird’s nest fungi
chemical structure
biological activity
chemical synthesis
biosynthesis
diterpene cyclase
