聚合物基仿生医用胶黏剂的开发与应用

Development and Applications of Polymeric Biomimetic Tissue Adhesives

生物医用胶黏剂有望代替手术缝合线用于伤口闭合,可广泛用于皮肤、内脏、心血管、骨和牙齿等软/硬组织伤口的再生修复,市场前景广阔;然而,在湿态下如何使其对生物组织产生强力黏附一直是科学界面临的难题。为解决这一难题,研究者模拟自然界中各种动、植物的黏附策略,开发了一系列仿生医用胶黏剂。本文总结了各种聚合物基仿生医用胶黏剂的开发及其在手术伤口黏合、日常伤口护理、慢性伤口再生修复、骨折黏合固定等软/硬组织再生修复以及局部药物递送和原位治疗等领域中的应用,并展望了医用胶黏剂的未来发展方向,包括其在医疗美容领域的应用前景。

As a potential substitute of surgical suture for wound closure use,biomedical/tissue adhesives can be widely used in the repair/regeneration of wounds on soft/hard tissue such as skin,viscera,cardiovascular,bone and teeth,possessing a broad market prospect.However,it is still a challenge for the science community to produce strong adhesion to tissues at wet state.To address this problem,scientists developed a series of biomimetic tissue adhesives by imitating the adhesion strategies of various animals and plants in nature.In this review,the development of various polymeric biomimetic medical/tissue adhesives and their applications in surgical wound adhesion,daily wound care,chronic wound regeneration,bone fracture fixation and other soft/hard tissue repair/regeneration,as well as local drug delivery and in situ therapy are summarized in detail.The future development trend of tissue adhesives is also prospected,including their application potential in the field of medical cosmetology.