期刊文献+

GDF-15与胃癌患者术后营养状态的相关性

Correlation between GDF-15 and nutritional status of patients after gastric cancer surgery
下载PDF
导出
摘要 目的:评估血清生长和分化因子15(GDF-15)与营养状态的相关性,为胃癌术后患者发生营养不良的临床诊疗提供新的临床思路和治疗靶点。方法:收集2019年3月—2020年3月收治的胃癌患者78例,根据TNM分期分为早期胃癌组和进展期胃癌组,分别在术前、术后14 d、术后30 d时收集两组患者的营养状态指标及GDF-15水平。用NRS-2002评分和PG-SGA评分评估患者的营养状态。结果:术后14 d时两组总白蛋白、白蛋白、前白蛋白均较术前降低(P<0.05),而GDF-15、NRS-2002评分和PG-SGA评分均显著高于术前(P<0.05)。术后30 d时早期胃癌组的营养状态较术后14 d有所恢复,但进展期胃癌组总白蛋白、白蛋白、前白蛋白仍低于术后14 d(P<0.05),GDF-15、NRS-2002评分和PG-SGA评分均显著高于术后14 d(P<0.05)。相关性分析结果显示术后14 d和术后30 d的GDF-15与前白蛋白显著负相关(r=-0.872、-0.895,P<0.05),与NRS-2002评分、PG-SGA评分正相关(r=0.262、0.401和0.551、0.436,P<0.05),在术后30 d时GDF-15与总蛋白质和白蛋白也表现出负相关性(r=-0.598、-0.503,P<0.05)。结论:胃癌术后患者GDF-15水平与前白蛋白和PG-SGA评分密切相关,营养状态越差,GDF-15水平越高,因此GDF-15可以作为评估胃癌患者术后营养状态的潜在生物标志物。 Objective:To assess the correlation between serum growth differentiation factor 15(GDF-15)and nutritional status,provide new clinical ideas and therapeutic targets for clinical diagnosis and treatment of malnutrition in patients after gastric cancer surgery.Methods:Collect 78 patients with gastric cancer admitted from March 2019 to March 2020,and divide them into early gastric cancer group and advanced gastric cancer group according to TNM staging.The nutritional status indicators and GDF-15 levels of the two groups of patients were collected before operation,14 days after operation,and 30 days after operation.NRS-2002 score and PG-SGA score were used to evaluate the nutritional status of patients.Results:At 14 d after operation,the total albumin,albumin,and prealbumin of the two groups of gastric cancer were lower than those before operation(P<0.05),while the GDF-15,NRS-2002 score and PG-SGA score were significantly higher than those before operation(P<0.05).The nutritional status of the early gastric cancer group recovered at 30 days postoperatively compared with 14 days postoperatively,but the total albumin,albumin,and prealbumin of the advanced gastric cancer group were still lower than those on the 14th day after surgery(P<0.05),GDF-15.Both NRS-2002 score and PG-SGA score were significantly higher than 14 days after operation(P<0.05).Correlation analysis showed that GDF-15 at 14 days and 30 days after surgery was significantly negatively correlated with prealbumin(r=-0.872,-0.895,P<0.05),and positively correlated with NRS-2002 score and PG-SGA score(r=0.262,0.401 and 0.551,0.436,P<0.05),At 30 days after operation,GDF-15 also showed a negative correlation with total protein and albumin(r=-0.598,-0.503,P<0.05).Conclusion:GDF-15 is closely related to prealbumin and PG-SGA scores in patients after gastric cancer surgery.The worse the nutritional status,the higher the GDF-15 level.Therefore,GDF-15 can be used as a potential biomarker for evaluating the nutritional status of gastric cancer patients after surgery.
作者 马海长 贾腾飞 依里牙尔·依里哈木 王理 MA Hai-zhang;JIA Teng-fei;Eliyar Elham;WANG Li(Department of Organ Transplantation,Qilu Hospital of Shandong University,Jinan 250012,China;Department of General Surgery,The First Affiliated Hospital of Xinjiang Medical University,Urumqi 830000,China;Department of Emergency Medicine,The Second Affiliated Hospital of Zhejiang University School of Medicine(Hangzhou 310000,China)
出处 《中国现代普通外科进展》 CAS 2021年第3期180-185,共6页 Chinese Journal of Current Advances in General Surgery
基金 2020新疆自治区卫生健康青年医学科技人才专项科研项目(WJWY-202014)。
关键词 生长和分化因子15 胃肿瘤 NRS-2002评分 PG-SGA评分 总白蛋白 白蛋白 前白蛋白 Growth and differentiation factor 15 Stomach tumor NRS-2002 score PG-SGA score Total albumin Albumin Prealbumin
  • 引文网络
  • 相关文献

参考文献6

二级参考文献9

共引文献50

相关主题

;
使用帮助 返回顶部