信号素3F及其受体神经纤毛蛋白在肿瘤微环境中的研究进展

Research progress of SEMA3F and its receptor NRP in tumor microenvironment

肿瘤微环境可以经不同信号通路分泌多种血管生成因子、炎性细胞因子和趋化因子,利用多种间质细胞组成的庞杂系统加快肿瘤的进展。其中信号素(semaphorins,SEMA)是肿瘤微环境的重要调节因子,信号素-神经纤毛蛋白(SEMA-NRP)复合物参与肿瘤抑制途径,本研究期望通过对肿瘤微环境中信号素3F(semaphorins 3F,SEMA3F)及其受体神经纤毛蛋白(neuropilin,NRP)作用的综述,为将来对肿瘤进行早期靶向治疗提供依据。

Tumor microenvironment is a complex system containing a variety of Leydig cells,which secrete a variety of inflammatory cytokines,chemokines and angiogenic factors through signaling pathways to accelerate tumor development.Among them,semaphorins(SEMA)is an important regulator of the tumor microenvironment,and semaphorins-neuropilin(SEMA-NRP)complex is involved in the tumor inhibition pathway.The role of SEMA3F and its receptor neuropilin(NRP)in tumor microenvironment is reviewed with a view to the early targeted therapy of tumors in the future.