银屑病相关肾脏损害的发病机制

Pathogenesis of Psoriasis-related Kidney Damage

银屑病被认为是一种免疫介导的慢性炎症性疾病,常累及皮肤和关节,目前已阐明其与糖尿病、高血压、代谢综合征、动脉粥样硬化等多种共存疾病有关。近年来国内外多个研究发现银屑病是慢性肾脏病和终末期肾病的独立危险因素,并提出“银屑病肾病”这一概念,银屑病本身及其治疗药物引起的肾脏损害备受关注,相关肾脏损害与炎症反应、氧化应激、免疫复合物沉积、肾素-血管紧张素-醛固酮系统过度激活、内皮功能障碍、胰岛素抵抗、脂肪因子紊乱、遗传和药物等因素有关。本文就银屑病相关肾脏损害的发病机制做一综述。

Psoriasis is considered to be an immune-mediated chronic inflammatory disease that often affects the skin and joints.It has been clarified that it is related to multiple coexisting diseases such as diabetes,hypertension,metabolic syndrome,and atherosclerosis.In recent years,many domestic and foreign studies have found that psoriasis is an independent risk factor for chronic kidney disease and end-stage renal disease,and proposed the concept of"psoriatic nephropathy".Kidney damage caused by psoriasis itself and its treatment drugs has attracted much attention.Related kidney damage and inflammation,oxidative stress,immune complex deposition,the renin-angiotensin-aldosterone system is over-activated,endothelial dysfunction,insulin resistance,adipokines disorders,genetics and drugs.This article reviews the pathogenesis of psoriasis-related kidney damage.