生长因子纳米载药系统促进组织修复的研究

Research on Growth Factor Nano Drug Delivery System Promoting Tissue Repair

生长因子在组织修复、创面愈合等方面发挥作用,但由于其在体内的不稳定性和毒性作用限制了临床应用范围,而新型的载药系统为生长因子类药物的控释提供了可能。目前常见用于载药系统的材料有脂质体、固体脂质纳米粒、纳米结构脂质体、多聚物、蛋白质和介孔二氧化硅等,而基于不同材料的载药系统具有不同的特性。本文就纳米载药系统的概述及优越性、常见纳米载药材料的分类、生长因子纳米载药系统的应用及其不足及改进策略作一综述,以期为生长因子类药物纳米载药系统的应用提供参考。

Growth factors play a role in tissue repair,wound healing,etc.,but their instability and toxicity in the body limit the scope of clinical application,and new drug delivery systems provide the possibility for the controlled release of growth factor drugs.At present,the materials commonly used in drug delivery systems include liposomes,solid lipid nanoparticles,nanostructured liposomes,polymers,proteins,and mesoporous silica,etc.However,drug delivery systems based on different materials have different characteristic.This article reviews the overview and advantages of nano drug delivery systems,the classification of common nano drug delivery materials,the application of growth factor nano drug delivery systems and their shortcomings and improvement strategies,with a view to the application of growth factor drug nano drug delivery systems for reference.