ST6GalⅠ在肾透明细胞癌中表达及其与病理特征的关系

The Expression of ST6GalⅠin Renal Clear Cell Carcinoma and Its Relationship with Pathological Features

目的探讨人β半乳糖苷α-2,6-唾液酸转移酶Ⅰ(ST6GalⅠ)在肾透明细胞癌(ccRCC)组织及正常肾组织中表达的差异及其与患者病理特征的关系。方法选择2013年1月~2019年12月来院就诊的ccRCC患者127例作为研究对象,取ccRCC患者癌组织作为研究组,癌旁正常肾组织作为对照组。免疫组化法检测两组ST6GalⅠ的表达,分析其表达与年龄、性别、肿瘤大小、分期及肿瘤分级的关系。结果免疫组化结果显示,研究组ST6GalⅠ表达水平高于对照组,差异有统计学意义(P<0.05);不同年龄、性别的ccRCC组织中ST6GalⅠ的表达比较,差异无统计学意义(P>0.05);不同肿瘤分期、大小、分级的ccRCC组织中ST6GalⅠ的表达比较,差异有统计学意义(P<0.05)。结论ST6GalⅠ在ccRCC组织中的表达水平高于正常肾脏组织,且肿瘤大小≥7 cm,分期为2期,分级为中低分化的ccRCC患者ST6GalⅠ表达阳性率也较高。

Objective To investigate the differences in the expression of humanβ-galactosideα-2,6-sialyltransferase I(ST6GalI)in clear cell renal cell carcinoma(ccRCC)tissues and normal renal tissues and its relationship with the pathological characteristics of patients.Methods 127 ccRCC patients who came to the hospital from January 2013 to December 2019 were selected as the research objects.The cancer tissue of ccRCC patients was selected as the research group,and the normal kidney tissue adjacent to the cancer was used as the control group.Immunohistochemical method was used to detect the expression of ST6GalI in the two groups,and the relationship between its expression and age,gender,tumor size,stage and tumor grade was analyzed.Results The results of immunohistochemistry showed that the expression level of ST6GalⅠin the study group was higher than that in the control group,the difference was statistically significant(P<0.05);There was no statistically significant difference in the expression of ST6GalⅠin ccRCC tissues of different ages and genders(P>0.05);There was a statistically significant difference in the expression of ST6GalI in ccRCC tissues of different tumor stages,sizes and grades(P<0.05).Conclusion The expression level of ST6GalI in ccRCC tissues is higher than that in normal kidney tissues,and the tumor size is≥7 cm,and the stage is stage 2.The positive rate of ST6GalI expression in ccRCC patients with moderate to poor differentiation is also higher.