盐酸米诺环素联合替硝唑治疗慢性牙周炎患者的疗效

Efficacy of Minocycline Hydrochloride Combined with Tinidazole in the Treatment of Patients with Chronic Periodontitis

目的探讨盐酸米诺环素联合替硝唑治疗慢性牙周炎患者的临床疗效。方法选择2018年2月~2020年2月我院收治的慢性牙周炎患者98例作为研究对象,按照随机数字表法分为观察组和对照组,每组49例。对照组采用盐酸米诺环素治疗,观察组在对照组基础上联合替硝唑治疗,比较两组临床疗效,牙周炎指标水平(PPD、GI、PAL、PLI、牙齿松动度)及不良反应发生情况。结果观察组临床有效率为95.92%,高于对照组81.63%,差异有统计学意义(P<0.05)。治疗后,两组PPD、GI、PAL、PLI、牙齿松动度水平较治疗前下降,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率为8.16%,与对照组的16.33%比较,差异无统计学意义﹙P>0.05﹚。结论盐酸米诺环素联合替硝唑治疗慢性牙周炎临床疗效确切,可有效改善患者牙周炎指标水平,促进牙周组织再生,且不良反应发生率小,应用安全性较高。

Objective To investigate the clinical efficacy of minocycline hydrochloride combined with tinidazole in the treatment of patients with chronic periodontitis.Methods 98 patients with chronic periodontitis admitted to our hospital from February 2018 to February 2020 were selected as the research objects,and were divided into observation group and control group according to the random number table method,with 49 cases in each group.The control group was treated with minocycline hydrochloride,and the observation group was treated with tinidazole on the basis of the control group.The clinical efficacy,periodontitis index levels(PPD,GI,PAL,PLI,tooth looseness)and the occurrence of adverse reactions were compared between the two groups.Results The clinical effective rate of the observation group was 95.92%,which was higher than 81.63%of the control group,the difference was statistically significant(P<0.05).After treatment,the levels of PPD,GI,PAL,PLI,and tooth looseness in the two groups were lower than before treatment,and the observation group was lower than the control group,the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 8.16%,compared with 16.33%in the control group,the difference was not statistically significant(P>0.05).Conclusion Minocycline hydrochloride combined with tinidazole has a definite clinical effect in the treatment of chronic periodontitis.It can effectively improve the index level of periodontitis in patients and promote the regeneration of periodontal tissue.The incidence of adverse reactions is small and the application safety is high.