血浆游离DNA检测在心血管系统疾病诊断中的应用

Application of cell-free DNA in the diagnosis of cardiovascular diseases

心血管疾病发病率和病死率居高不下,寻求敏感性高的生物学指标帮助早期诊断和改善预后意义重大。血浆游离DNA(cell-free DNA, cfDNA)是一类存在于血浆、尿液及其他体液中游离于细胞之外的双链DNA片段。血浆cfDNA水平在心血管疾病的早期明显升高,提示其可能是心血管疾病的潜在生物标志物。为了更深入理解cfDNA在心血管疾病中的研究进展,本文就cfDNA的生物学特性、在心血管疾病中的作用和应用进展进行了总结。

It is considerable to seek new biomarkers with high sensitivity for early diagnosis due to high morbidity and mortality of cardiovascular diseases. Plasma cell free DNA(cfDNA) is a type of doublestranded DNA fragment existed in plasma, urine and other body fluids. Plasma cfDNA level is increased in the early stage of cardiovascular disease and suggest it may be a potential biomarker for cardiovascular disease. In this review, we summarized the biological characteristics of cfDNA, its biological roles and applications in cardiovascular diseases for a profound understanding and perspective on the clinical significance of cfDNA in cardiovascular diseases.