MiR-491在非小细胞肺癌发生发展过程中的作用机制研究

Research on the mechanism of miR-491 in the occurrence and development of non-small cell lung cancer

人类miR-491(has-miR-491)是一段长度为84 bp的微小RNA,可以通过与靶mRNA的3′端非翻译区(3′-untranslated region, 3′-UTR)结合,降解靶mRNA或抑制其翻译,在转录后水平对肿瘤细胞基因表达进行调控,影响肿瘤发展进程。非小细胞肺癌(non-small lang cancer, NSCLC)是导致全球肺癌发病率和死亡率升高的主要原因。MiR-491通过抑制下游靶蛋白,如C-MYC、IGF2BP1、MMP9、ZNF703、CAPG等,对NSCLC的增殖、迁移、侵袭等方面进行调控。推测其可以作为NSCLC临床诊断、预后的潜在生物标志物,并有可能成为NSCLC基因及药物治疗的靶点。

Human miR-491(has-miR-491) is a microRNA with a length of 84 bp, which can degrade the target protein or inhibit its translation by binding to the 3′-untranslated region(3′-UTR) of the target protein mRNA, regulating tumor progression at the post-transcriptional level. Non-small cell lung cancer(NSCLC) is the main cause of the global increase in lung cancer incidence and mortality. Studies have shown that miR-491 can regulate the proliferation, migration and invasion of NSCLC by inhibiting some downstream target proteins, such as C-MYC, IGF2 BP1, MMP9, ZNF703, CAPG, etc. It is inferred that miR-491 can be used as a potential biomarker for clinical diagnosis and prognosis of NSCLC, and may become a target for gene and drug treatment of NSCLC.