泛素E3连接酶接头蛋白SPOP和MDM2在DNA损伤修复中的作用

The Roles of E3 Adaptor SPOP and MDM2 in the DNA Damage Repair

DNA损伤修复是维持细胞基因组稳定性和完整性的基础,越来越多的研究发现,E3泛素连接酶在DNA损伤修复中起着重要的作用。该文将介绍DNA损伤修复的机制、DNA损伤修复与疾病的关系、及E3泛素连接酶接头蛋白MDM2和SPOP在DNA损伤修复中的作用。重点围绕DNA损伤修复的两条通路:E3泛素连接酶接头蛋白SPOP与ATM/ATR信号通路以及MDM2/p53信号通路对DNA修复的分子机制进行总结,以期为DNA损伤修复提供新思路。

DDR(DNA damage repair)is the basis for maintaining the stability and integrity of the cell genome.More and more researches find that E3 ubiquitin-protein ligase plays an important role in DDR.This review analyzes the mechanisms of DDR,the relationships between DDR and diseases,and the roles of E3 ubiquitin-protein ligases,such as MDM2 and SPOP,in DDR.Moreover,the molecular mechanisms of DDR in two key signal pathways were summarized,including E3 ubiquitin-protein ligase SPOP and ATM(ataxia-telangiectasia mutated)/ATR(ATM and Rad3-related)pathway,as well as E3 ubiquitin-protein ligase MDM2 and p53 pathway.This review looks forward to providing new ideas for DDR.