双刃剑:自噬与肿瘤发生发展的关系及相关靶点小分子药物研究进展

Double-Edged Sword:the Relationship between Autophagy and Tumorigenesis and the Development of Small-Molecule Drugs

自噬是哺乳动物细胞内重要且复杂的生理活动,同样影响着肿瘤的发生与进展。随着抗肿瘤药物的广泛使用,肿瘤耐药问题日益突出,影响患者预后。多年研究显示,肿瘤自噬与耐药密切相关。目前,已有越来越多的自噬相关小分子药物被用来调节肿瘤自噬活动,以求其能被广泛运用于抗癌方案之中。该文将针对自噬在癌症发生发展过程中的分子机制及相关小分子药物的研究进展进行综述,以期对肿瘤相关的自噬活动有更深入的认识,并为后期药物开发工作提供借鉴。

Autophagy is an important and complex physiological activity in mammalian cells,which also affects the occurrence and progression of tumors.With the widely use of anti-tumor drugs,the problem of tumor resistance becomes increasingly prominent,which affects the prognosis of patients.At present,various kinds of small molecule drugs related to autophagy have been used to find out"one shot fits all"strategies to conquer drug resistance problem in tumor.This article reviews the molecular mechanism of autophagy in tumorigenesis and the research progress of related small molecule drugs,to have a deeper understanding of cancer-related autophagy activities and provide references for future drug development.