细胞焦亡参与肿瘤发生分子机制的研究进展

Advances in the Molecular Mechanism of Pyroptosis Involved in the Occurrence of Tumors

细胞焦亡是一种依赖gasdermin家族蛋白的成孔活性,由半胱氨酸–天冬氨酸特异性蛋白激酶1、4、5、11等介导的以细胞肿胀、质膜穿孔及炎性小分子的释放为特征的新的裂解性、促炎性程序性细胞死亡。目前发现,细胞焦亡参与了多种疾病的发生与发展过程,特别是对肿瘤及肿瘤微环境的形成具有促进及抑制的双重功能,使焦亡成为抗肿瘤药物研究的最新热点之一。该文主要就细胞焦亡在肿瘤发生中的分子机制进行综述,讨论细胞焦亡对肿瘤治疗的意义,以期为肿瘤的靶向治疗提供参考。

Pyroptosis is a new lytic,pro-inflammatory programmed cell death characterized by cell swelling,plasma membrane perforation,and release of inflammatory small molecules.It is a programmed cell death model mediated by cysteine aspartic acid specific protein kinase 1,4,5,11,which mainly depends on the pore-forming activity of Gasdermin protein family.At present,it is found that pyroptosis participates in the occurrence and development of many diseases,especially its dual functions of promoting and inhibiting the formation of tumor and tumor microenvironment.It makes pyroptosis becomes one of the latest hot spots in the research of anti-tumor drugs.In this paper,the molecular mechanism of cell pyrosis in tumorigenesis is reviewed.The significance of pyroptosis in cancer treatment is discussed in order to provide a reference for targeted therapy of tumors.