左右半结肠癌多组学分子特征差异的研究进展

Recent Progress of Differences between Left-Sided and Right-Sided Colon Cancer on Multi-Omics Molecular Characteristics

结肠癌(colon cancer,CC)是一种常见的恶性肿瘤,其发病率和死亡率均占癌症前列。根据解剖学位置,CC可分为左半结肠癌(left-sided colon cancer,LCC)和右半结肠癌(right-sided colon cancer,RCC),两者在临床特征上表现出较大的差异。近些年来,随着生物学技术和测序技术的发展,从多组学角度分析LCC和RCC分子特征和微环境差异的研究也越来越多,从而来揭示患者预后并指导其治疗。该文从基因突变、基因表达、miRNA表达、DNA甲基化、免疫微环境、共识分子亚型以及免疫治疗这几个方面来阐述LCC和RCC在分子特征和治疗差异上的研究进展。

CC(colon cancer)is a type of the common malignant tumor with high morbidity and mortality.Based on the anatomical location of primary cancer site,CC can be divided into LCC(left-sided colon cancer)and RCC(right-sided colon cancer).There is a large heterogenicity between the patients with LCC and RCC in clinical characteristics.Due to the development of biological technology and sequencing technology,more and more studies have been conducted to identify the differences of molecular characteristics and microenvironment between LCC and RCC through multi-omics approach during the last decade.And these findings are used to guide the treatment and prognosis of CC patients.This review summarizes the recent progress of distinct molecular characteristics and treatment between LCC and RCC patients from the views of gene mutation,gene expression,miRNA expression,DNA methylation,immune microenvironment,immunotherapy and consensus molecular subtypes.