宫颈癌患者血清叶酸、细胞凋亡信号受体蛋白、辅助性T细胞17表达与人乳头状瘤病毒感染的关系研究

Relationship between FA,Fas,Th17 expression and HPV infection in cervical cancer patients

目的分析宫颈癌患者FA、Fas、Th17表达与H PV感染的关系。方法将本院2017年1月-2019年9月收治的308例宫颈癌作为观察组,100例健康体检女性作为对照组;检测血清中FA、Fas、Th17水平及阴道组织中HPV水平。结果HPV感染患者血清中FA及Fas明显低于未感染者,Th17明显高于未感染者,差异均有统计学意义(P<0.05);宫颈癌患者HPV感染是影响患者血清中FA、Fas及Th17水平的独立性影响因素(P<0.05)。结论宫颈癌患者血清中FA、Fas明显降低,Th17显著升高,且HPV感染是影响患者血中FA、Fas及Th17水平的独立性因素。

Objective To analyze the relationship between the expression of FA,Fas,Th17 and HPV infection in patients with cervical cancer was analyzed. Methods The 308 cases of cervical cancer treated in our hospital from January 2017 to September 2019 were used as the observation group,and 100 healthy women were used as the control group;the levels of FA,Fas,Th17 in the blood and HPV levels in the vaginal tissue were detected. Results The blood FA and Fas of patients with HPV infection were significantly lower than those without infection,and Th17 was significantly higher than those without infection,and the difference was statistically significant( P < 0. 05);HPV infection is an independent influencing factor for FA,Fas and Th17 levels in patients with cervical cancer. Conclusion The levels of FA,Fas and Th17 in the blood of patients with cervical cancer were significantly decreased and Th17 was significantly increased. HPV infection was an independent factor affecting the levels of FA,Fas and Th17 in the blood of patients with cervical cancer.