脓毒症致急性肾损伤(AKI)患者采用连续性肾脏替代疗法(CRRT)治疗的临床效果

Clinical Effect of Continuous Renal Replacement Therapy(CRRT)in Patients with Sepsis-induced Acute Kidney Injury(AKI)

目的研究脓毒症致急性肾损伤(acute kidney injury,AKI)患者实施连续性肾脏替代疗法(continuous renal replacement therapy,CRRT)治疗的临床治疗效果。方法选择2017年10月—2019年10月收治的100例该院所收治的脓毒症致急性肾损伤(AKI)患者作为研究案例,随机将患者分成实验组和对照组,每组50例。对照组接受常规治疗,连续性肾脏替代疗法为实验组治疗方法,比较两组患者的治疗满意度、治疗效果、C-反应蛋白、血肌酐、血尿素氮、尿量及其恢复时间,ICU治疗时间和心血管事件发生概率。结果实验组患者治疗满意度评分以及治疗满意率[(93.58±2.24)分、98.00%]均高于对照组[(85.14±3.14)分、74.00%],差异有统计学意义(t=15.473,χ^(2)=10.698,P<0.05)。实验组患者的治疗效果(96.00%)与对照组(80.00%)相比,差异有统计学意义(χ^(2)=6.061,P=0.014)。实验组患者的C-反应蛋白、血肌酐、血尿素氮优于对照组患者,差异有统计学意义(P<0.05)。实验组患者的尿量恢复时间以及ICU治疗时间[(7.88±2.17)d、(8.72±2.38)d]优于对照组患者,差异有统计学意义(t=5.614、6.490,P<0.05)。实验组患者的心血管事件发生率(2.00%)低于对照组患者(14.00%),差异有统计学意义(χ^(2)=5.837,P=0.092)。结论连续性肾脏替代疗法可以有效地消除患者的炎性介质,改善患者的肾功能,增加患者的治疗满意度。

Objective To study the clinical effect of continuous renal replacement therapy(CRRT)in patients with acute kidney injury(AKI)caused by sepsis.Methods Selected 100 sepsis-induced acute kidney injury(AKI)patients admitted to this hospital from October 2017 to October 2019 as research cases,and randomly divided the patients into experimental and control groups,with 50 cases in each group.The control group received conventional treatment,and continuous renal replacement therapy was the treatment method of the experimental group.The treatment satisfaction,treatment effect,C-reactive protein,blood creatinine,blood urea nitrogen,urine output and recovertime of the two groups were compared and contrasted,ICU Treatment time and probability of cardiovascular events.Results The treatment satisfaction score and treatment satisfaction rate of the experimental group of patients[(93.58±2.24)points,98.00%]were higher than those of the control group[(85.14±3.14)points,74.00%],the difference were statistically significant(t=15.473,χ^(2)=10.698,P<0.05).Compared with the control group(80.00%),the treatment effect of the experimental group(96.00%)was statistically significant(χ^(2)=6.061,P=0.014).The C-reactive protein,blood creatinine,and blood urea nitrogen of the experimental group were better than those of the control group,and the difference was statistically significant(P<0.05).The recovery time of urine output and ICU treatment time[(7.88±2.17)d,(8.72±2.38)d]of the experimental group were better than those of the control group,the difference was statistically significant(t=5.614,6.490,P<0.05).The incidence of cardiovascular events in the experimental group(2.00%)was lower than that in the control group(14.00%),and the difference was statistically significant(χ^(2)=5.837,P=0.092).Conclusion In this research investigation,it can be clearly concluded that continuous kidney replacement therapy can effectively eliminate patients'inflammatory mediators,improve patients'renal function,and increase patients'satisfaction with treatment.