解析阿托伐他汀对急性心肌梗死冠脉介入治疗后早期血脂及近期心血管事件的临床效果

Analysis on the Clinical Effect of Atorvastatin on Early Blood Lipids and Recent Cardiovascular Events after Coronary Interventional Therapy for Acute Myocardial Infarction

目的探究阿托伐他汀对急性心肌梗死患者冠脉介入治疗后早期血脂及近期心血管事件的影响效果。方法将2016年8月—2018年12月作为研究时间段,回顾性分析该院在研究时间段内收治的72例急性心肌梗死患者的临床资料,按照患者经冠脉介入治疗后给药方式的不同,将所有研究对象平均分成对照组与研究组两个组别。对照组施以中强度用药,研究组施以高强度用药,对比两组患者经阿托伐他汀用药后的低密度脂蛋白(LDC-C)、超敏C-反应蛋白(hs-CRP)、总胆固醇、高密度脂蛋白(HDL-C)等早期血脂水平及近期心血管事件发生情况。结果治疗前两组患者低密度脂蛋白(LDC-C)、超敏C-反应蛋白(hs-CRP)、总胆固醇、高密度脂蛋白(HDL-C)等早期血脂水平比较差异无统计学意义(P>0.05),经治疗,研究组患者的低密度脂蛋白指标为(1.61±0.63)mmol/L,总胆固醇(2.83±0.36)mmol/L,与对照组[(2.46±1.02)mmol/L、(3.62±0.44)mmol/L]相比差异有统计学意义(t=4.254、8.338,P<0.05),其他指标如超敏C-反应蛋白和高密度胆固醇水平对比差异无统计学意义(P>0.05),研究组患者心血管事件发生率为2.78%,对照组为19.44%,两组数据对比,差异有统计学意义(χ^(2)=3.516,P<0.05)。结论40 mg/d的阿托伐他汀治疗方法,针对急性心肌梗死实施冠状动脉介入治疗后的患者有较为理想的治疗效果。

Objective To explore the effect of atorvastatin on early blood lipids and short-term cardiovascular events in patients with acute myocardial infarction after coronary intervention.Methods Using August 2016 to December 2018 as the study time period,the study retrospectively analyzed the clinical data of 72 patients with acute myocardial infarction admitted to the hospital during the study time period,according to the different patient's administration method after coronary intervention,all research subjects were equally divided into two groups:control group and study group.The control group was given medium-intensity medication and the study group was given high-intensity medication.The low-density lipoprotein(LDC-C),high-sensitivity C-reactive protein(hs-CRP),early blood lipid levels such as total cholesterol and high-density lipoprotein(HDL-C)and recent cardiovascular events.Results Before treatment,there was no statistically significant difference in the early blood lipid levels of low-density lipoprotein(LDC-C),high-sensitivity C-reactive protein(hs-CRP),total cholesterol,and high-density lipoprotein(HDL-C)between the two groups(P>0.05).For treatment,the low-density lipoprotein index of the study group was(1.61±0.63)mmol/L,total cholesterol(2.83±0.36)mmol/L,and the control group[(2.46±1.02)mmol/L,(3.62±0.44)mmol/L],the difference was statistically significant(t=4.254,8.338,P<0.05),and other indicators such as hypersensitive C-reactive protein and high density,had no statistically significant difference in cholesterol levels(P>0.05).The incidence of cardiovascular events was 2.78%in the study group and 19.44%,comparison of the two groups of data,the difference was statistically significant(χ^(2)=3.516,P<0.05).Conclusion The 40 mg/d atorvastatin treatment has an ideal therapeutic effect for patients with acute myocardial infarction after coronary interventional therapy.