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瑞舒伐他汀与阿托伐他汀治疗早发冠心病急性心肌梗死的效果比较 被引量:8

Comparison of the Effects of Rosuvastatin and Atorvastatin in the Treatment of Premature Coronary Heart Disease and Acute Myocardial Infarction
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摘要 目的对早发冠心病急性心肌梗死患者采用瑞舒伐他汀和阿托伐他汀治疗的效果进行探究。方法选择2018年1月—2020年2月该院收治的早发冠心病急性心肌梗死患者120例作为该次研究的纳入对象。通过随机盲选的方式对这些患者实施分组处理,分为甲组和乙组,每组60例。在常规治疗的基础上,采用阿托伐他汀对甲组予以治疗,采用瑞舒伐他汀对乙组予以治疗。比较两组的疗效。结果乙组在总有效率(96.7%)明显优于甲组,差异有统计学意义(χ^(2)=8.086,P<0.05);治疗后,乙组的总胆固醇(3.0±0.2)mmol/L、超敏C反应蛋白(4.5±0.3)mg/L、低密度脂蛋白(1.6±0.3)mmol/L明显优于甲组,差异有统计学意义(t=20.137、70.179、12.701,P<0.05);乙组在不良心血管事件发生率5.0%与甲组6.7%差异无统计学意义(χ^(2)=0.000,P>0.05)。结论在早发冠心病急性心肌梗死患者的治疗中,应用瑞舒伐他汀具有很好的效果,其能够有效改善患者的血脂指标,而且可以减少不良反应。 Objective To explore the effect of rosuvastatin and atorvastatin in patients with premature coronary heart disease and acute myocardial infarction.Methods 120 patients with premature coronary heart disease and acute myocardial infarction admitted to the hospital were selected as the subjects of this study,and the selection time was from January 2018 to February 2020.These patients were divided into groups A and B by random blind selection,with 60 cases in each group.On the basis of conventional treatment,atorvastatin was used to treat group A,and rosuvastatin was used to treat group B.Compared the efficacy of the two groups.Results The total effective rate of group B(96.7%)was significantly better than that of group A.The difference was statistically significant(χ^(2)=8.086,P<0.05);after treatment,the total cholesterol of group B(3.0±0.2)mmol/L,hypersensitivity C-reactive protein(4.5±0.3)mg/L and low-density lipoprotein(1.6±0.3)mmol/L were significantly better than group A.The difference was statistically significant(t=20.137,70.179,12.701,P<0.05);group B There was no statistically significant difference in the incidence of adverse cardiovascular events between 5.0%and 6.7%in group A.The difference was not statistically significant(χ^(2)=0.000,P>0.05).Conclusion In the treatment of patients with premature coronary heart disease and acute myocardial infarction,the application of rosuvastatin has a very good effect.It can effectively improve the patient's blood lipids and reduce adverse reactions.
作者 许培义 刘华 XU Pei-yi;LIU Hua(Department of Pharmacy,Tengzhou Central People's Hospital,Tengzhou,Shandong Province,277500 China)
出处 《世界复合医学》 2021年第1期190-192,共3页 World Journal of Complex Medicine
关键词 瑞舒伐他汀 阿托伐他汀 早发冠心病急性心肌梗死 疗效 血脂指标 不良反应 Rosuvastatin Atorvastatin Early-onset coronary heart disease and acute myocardial infarction Curative effect Blood lipid index Adverse reactions
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