不同糖化血红蛋白水平的2型糖尿病患者血浆皮质醇水平及临床意义

Plasma Cortisol Levels in Type 2 Diabetes Patients with Different Glycosylated Hemoglobin Levels and Its Clinical Significance

目的探讨不同糖化血红蛋白(HbA1c)水平的2型糖尿病(T2DM)患者血清皮质醇水平与血糖、胰岛素抵抗的相关性。方法选取2019年3月—2020年5月期间在该院检测过皮质醇的T2DM患者106例,分为HbA1c≤7%。7%组和HbA1c>7%组。对比分析两组患者的血清皮质醇(8:00)水平的差异以及其与空腹血糖(FBG)、HbA1c、HOMA指数(HOMA-IR)之间的相关性。结果HbA1c>7%组的血清皮质醇(8:00)、FBG、HbAlc及HOMA-IR水平显著高于HbA1c≤7%组,差异有统计学意义(P<0.05);全部T2DM患者血清皮质醇(8:00)水平与FBG、HbA1c呈正相关(P<0.05)。结论T2DM患者存在血清皮质醇(8:00)水平增高,且皮质醇分泌过高的程度与患者血糖水平的高低密切相关,可将血浆皮质醇作为血糖控制情况的评价指标之一。

Objective To investigate the correlation between serum cortisol levels and blood sugar and insulin resistance in patients with type 2 diabetes(T2DM)with different levels of glycosylated hemoglobin(HbA1c).Methods A total of 106 T2DM patients with cortisol tested in the hospital from March 2019 to May 2020 were selected and divided into HbA1c≤7%group and HbA1c>7%group.The differences in serum cortisol(8:00)levels of the two groups of patients were compared and analyzed and their correlation with fasting blood glucose(FBG),HbA1c,and HOMA index(HOMA-IR).Results The levels of serum cortisol(8:00),FBG,HbAlc and HOMA-IR in the HbA1c>7%group were significantly higher than those in the HbA1c≤7%group,the difference was statistically significant(P<0.05);serum cortisol in all T2DM patients(8:00)level was positively correlated with FBG and HbA1c(P<0.05).Conclusion Patients with T2DM have increased serum cortisol(8:00)levels,and the excessive secretion of cortisol is closely related to the blood glucose level of patients.Plasma cortisol can be used as one of the evaluation indicators of blood glucose control.