糖尿病足部感染患者病原菌检验与耐药性分析

Pathogen Test and Drug Resistance Analysis in Patients with Diabetic Foot Infection

目的研究糖尿病足部感染患者病原菌检验与耐药性。方法于该院2019年5月—2020年5月间糖尿病足感染患者中随机抽取63例,收集病历资料,回顾性分析病原菌及耐药性。结果63例患者共分离病原菌株87株,其中42例(66.7%)患者检出2种以上病原菌。其中包括革兰阴性菌25株(28.7%),革兰阳性菌62株(71.2%)。美罗培南和亚胺培南对大肠埃希菌药敏性达到100.0%,对铜绿假单胞菌药敏性达到88.9%,对肺炎克雷伯菌药敏性达75.0%,和其他抗生素相比,差异有统计学意义(P<0.05)。替考拉宁对金黄色葡萄球菌具有较高敏感性(100.0%),其他抗生素药物敏感性一般,差异有统计学意义(P<0.05)。各抗生素药物对肠球菌敏感性一般,各抗生素之间差异无统计学意义(P>0.05)。结论对糖尿病足感染患者进行病原菌检验,发现大部分患者感染多种病原菌,病原菌的耐药性强,必须要根据患者病原菌种类选择药敏性更高的抗生素药物治疗,才能提高预后转归率。

Objective To study the pathogen test and drug resistance in patients with diabetic foot infection.Methods From May 2019 to May 2020,63 patients with diabetic foot infections were randomly selected,medical records were collected,and pathogenic bacteria and drug resistance were retrospectively analyzed.Results A total of 87 pathogenic strains were isolated from 63 patients,of which 42(66.7%)patients were detected with more than two pathogenic bacteria.Including 25 strains(28.7%)of gram-negative bacteria,62 strains(71.2%)of gram-positive bacteria.Meropenem and imipenem are 100.0%susceptible to Escherichia coli,88.9%to Pseudomonas aeruginosa,and 75.0%to Klebsiella pneumoniae.Compared with other antibiotics,the difference was statistically significant(P<0.05).Teicoplanin has a high sensitivity(100.0%)to Staphylococcus aureus,while other antibiotics are generally sensitive,and the difference was statistically significant(P<0.05).The sensitivity of antibiotics to enterococci was general,and there was not statistically significant difference between antibiotics(P>0.05).Conclusion The pathogenic bacteria test for patients with diabetic foot infection found that most of the patients were infected with multiple pathogens,and the pathogens are highly resistant.It is necessary to select antibiotics with higher drug sensitivity according to the types of pathogens of the patients to improve the prognosis rate.