依帕司他治疗糖尿病周围神经病变的效果分析

Analysis of the Effect of Epalrestat in the Treatment of Diabetic Peripheral Neuropathy

目的对糖尿病周围神经病变患者采用依帕司他治疗的效果进行研究。方法选择该院2019年1月—2020年1月收治的糖尿病周围神经病变患者104例作为该次研究纳入的研究对象,按照随机数字表法将其划分为常规组和联合组,每组52例。采用甲钴胺治疗常规组患者,在此基础上,采用依帕司他治疗联合组。对两组患者的治疗效果进行观察和比较。结果联合组的疗效明显优于常规组,差异有统计学意义(P<0.05);联合组的血糖水平与常规组比较差异无统计学意义(P>0.05);联合组的神经传导速度明显优于常规组,差异有统计学意义(P<0.05);联合组的不良反应率与常规组比较差异无统计学意义(P>0.05)。结论针对糖尿病周围神经病变患者采用依帕司他治疗效果确切,可以有效改善患者的神经传导速度,而且不良反应较少。

Objective To study the effect of epalrestat treatment in patients with diabetic peripheral neuropathy.Methods A total of 104 patients with diabetic peripheral neuropathy admitted to the hospital from January 2019 to January 2020 were selected as the subjects of this study.They were divided into the conventional group and the combined group according to the random number table method,each group had 52 cases.Patients in the conventional group were treated with mecobalamin,and on this basis,the combined group was treated with epalrestat.Observe and compare the treatment effects of the two groups of patients.Results The curative effect of the combined group was significantly better than that of the conventional group.The difference was statistically significant(P<0.05);there was not significant difference in blood glucose levels between the combined group and the routine group(P>0.05);the nerve conduction velocity of the combined group was significantly better than that of the conventional group,the difference was statistically significant(P<0.05);The adverse reaction rate of the combined group was not statistically different from that of the conventional group(P>0.05).Conclusion The treatment effect of epalrestat for patients with diabetic peripheral neuropathy is definite,which can effectively improve the nerve conduction velocity of patients with fewer adverse reactions.