美沙拉嗪与双歧杆菌三联活菌联合治疗溃疡性结肠炎的效果分析

Analysis of the Effect of Combined Treatment of Ulcerative Colitis with Mesalazine and Bifidobacterium Triple Viable Bacteria

目的评价美沙拉嗪与双歧杆菌三联活菌联合治疗溃疡性结肠炎的效果。方法对2018年8月—2019年10月前来该院就诊的溃疡性结肠炎患者104例作为该次研究的对象,随机分为对照组(美沙拉嗪治疗)与观察组(美沙拉嗪治疗基础采用双歧杆菌三联活菌治疗),各52例。观察与比较两组患者超敏C反应蛋白、白细胞介素6与肿瘤坏死因子α水平、生活质量评分、不良反应发生率以及治疗总有效率。结果治疗后,观察组患者超敏C反应蛋白(9.01±2.34)mg/L、白细胞介素6(93.55±10.86)ng/L与肿瘤坏死因子α(16.03±4.24)ng/L水平均低于对照组(16.89±2.48)mg/L、(147.41±12.92)ng/L、(24.93±4.38)ng/L,差异有统计学意义(t=16.665、23.012、10.528,P<0.05);观察组不良反应发生率1.92%、治疗总有效率96.15%优于对照组的17.31%、80.77%,差异有统计学意义(χ^(2)=7.271、6.029,P<0.05)。结论在美沙拉嗪治疗溃疡性结肠炎的基础上,采用双歧杆菌三联活菌联合治疗更显著改善患者体内炎性因子水平,可以更显著提高患者生活质量,其疗效与安全性均高于单一用药。

Objective To evaluate the effect of mesalazine and bifidobacterium triple viable bacteria in the treatment of ulcerative colitis.Methods A total of 104 patients with ulcerative colitis who came to the hospital from August 2018 to October 2019 were selected as the subjects of this study.They were randomly divided into a control group(mesalazine treatment)and an observation group(on the basis of mesalamine treatment,bifidobacteria triple live bacteria treatment),52 cases each.Observed and compared the levels of hypersensitivity c-reactive protein,interleukin-6 and tumor necrosis factor alpha,quality of life score,incidence of adverse reactions,and total effective rate of treatment between the two groups.Results After treatment,the observation group patients'hypersensitivity c-reactive protein(9.01±2.34)mg/L,interleukin 6(93.55±10.86)ng/L and tumor necrosis factorα(16.03±4.24)ng/L levels were lower than the control group of(16.89±2.48)mg/L,(147.41±12.92)ng/L,(24.93±4.38)ng/L,the difference was statistically significant(t=16.665,23.012,10.528,P<0.05);the incidence of adverse reactions in the observation group was 1.92%,the total effective rate of treatment was 96.15%better than that of the control group 17.31%and 80.77%,the difference was statistically significant(χ^(2)=7.271,6.029,P<0.05).Conclusion On the basis of mesalazine in the treatment of ulcerative colitis,the combined treatment of triple viable bifidobacteria can significantly improve the level of inflammatory factors in the patient's body,and can more significantly improve the quality of life of the patient,and its efficacy and safety are higher than that of single medication.