七氟烷吸入麻醉与靶腔输注丙泊酚对老年消化道肿瘤术后认知功能的影响

Effects of Sevoflurane Inhalation Anesthesia and Target Cavity Infusion of Propofol on the Cognitive Function of Elderly Patients with Gastrointestinal Tumors

目的探究老年消化道肿瘤患者行七氟烷吸入麻醉与靶腔输注丙泊酚对术后认知功能的影响。方法选取该院2018年1—12月收治的80例老年消化道肿瘤患者为研究对象,均行气管插管全身麻醉,按照随机数字表法分为两组,对照组、观察组分别行七氟烷吸入麻醉、靶腔输注丙泊酚麻醉,对比两组麻醉情况、POCD(认知功能障碍)发生情况、MMSE(美国简易智能精神状态检查量表)评分。结果观察组定向力恢复时间、拔管时间、睁眼时间分别为(15.02±1.08)min、(12.28±0.28)min、(10.02±0.18)min,均短于对照组,差异有统计学意义(t=18.393、24.375、41.373,P<0.05);观察组手术后6 h MMSE评分为(28.12±0.09)分,高于对照组,差异有统计学意义(t=137.948,P<0.05);观察组术后POCD发生率为2.50%,低于对照组,差异有统计学意义(χ^(2)=4.507,P<0.05)。结论相较于七氟烷吸入麻醉,老年消化道肿瘤患者行靶腔输注丙泊酚麻醉的效果理想,对术后认知功能的影响小。

Objective To explore the effects of sevoflurane inhalation anesthesia and target cavity infusion of propofol on postoperative cognitive function in elderly patients with gastrointestinal tumors.Methods A total of 80 elderly patients with gastrointestinal tumors admitted to the hospital from January to December 2018 were selected as the research objects.All of them underwent general anesthesia with tracheal intubation.They were divided into two groups according to the random number table,the control group and the observation group.Sevoflurane inhalation anesthesia and target cavity infusion of propofol anesthesia were performed,and the anesthesia,POCD(cognitive dysfunction)occurrence,and MMSE(American Simple Mental State Examination Scale)scores were compared between the two groups.Results The orientation recovery time,extubation time,and eye opening time of the observation group were(15.02±1.08)min,(12.28±0.28)min,and(10.02±0.18)min,respectively,which were shorter than those of the control group,and the difference was statistically significant(t=18.393,24.375,41.373,P<0.05);the 6 h MMSE score of the observation group after surgery was(28.12±0.09)points,which was higher than that of the control group,and the difference was statistically significant(t=137.948,P<0.05);the postoperative POCD rate of the observation group was 2.50%,which was lower than the control group,and the difference was statistically significant(χ^(2)=4.507,P<0.05).Conclusion Compared with sevoflurane inhalation anesthesia,target cavity infusion of propofol anesthesia in elderly patients with gastrointestinal tumors has an ideal effect,and has little effect on postoperative cognitive function.