高剂量丙种球蛋白辅助治疗重型再生障碍性贫血的效果分析

Analysis of the Effect of High-dose Gamma Globulin in Adjuvant Treatment of Severe Aplastic Anemia

目的针对重型再生障碍性贫血患者采用高剂量丙种球蛋白治疗的临床效果进行探究。方法选择该院2017年7月—2019年4月收治的重型再生障碍性贫血患者共计62例作为该次研究的对象,按照随机数字表法将其划分为高剂量组和低剂量组,每组31例。采用高剂量病种球蛋白治疗高剂量组,采用低剂量丙种球蛋白辅助治疗低剂量组,对两组患者的治疗效果进行观察和比较。结果总缓解率方面:高剂量组总缓解率93.5%明显高于低剂量组总缓解率67.7%,两组患者比较差异有统计学意义(χ^(2)=6.613,P<0.05);不良反应发生率方面:低剂量组在治疗期间出现高血压2例,肾功能损害1例,牙龈增生1例,不良反应发生率12.9%,高剂量组在治疗期间出现高血压1例,肾功能损害2例,不良反应发生率9.7%,高剂量组略低于低剂量组,但两组患者比较差异无统计学意义(χ^(2)=0.000,P>0.05)。结论针对重型再生障碍性贫血患者实施高剂量丙种球蛋白辅助治疗效果确切,而且不良反应较低,具有比较高的安全性。

Objective To explore the clinical effects of high-dose gamma globulin treatment in patients with severe aplastic anemia.Methods A total of 62 patients with severe aplastic anemia admitted to the hospital from July 2017 to April 2019 were selected as the subjects of this study.They were divided into high-dose and low-dose groups according to the random number table method,31 patients in each group.The high-dose globulin was used to treat the high-dose group,and the low-dose gamma globulin was used as an adjuvant treatment for the low-dose group.The therapeutic effects of the two groups were observed and compared.Results The overall response rate:93.5%of the high-dose group was significantly higher than the low-dose group of 67.7%.The difference between the two groups of patients was statistically significant(χ^(2)=6.613,P<0.05);the incidence of adverse reactions:in the low dose group,2 cases of hypertension occurred during the treatment,1 case of renal dysfunction,1 case of gingival hyperplasia,and the incidence of adverse reactions was 12.9%.In the high-dose group,1 case of hypertension and 2 cases of renal dysfunction occurred during the treatment,and adverse reactions occurred.The rate was 9.7%.The high-dose group was slightly lower than the low-dose group,but the difference between the two groups of patients was not statistically significant(χ^(2)=0.000,P>0.05).Conclusion The effect of high-dose gamma globulin adjuvant therapy for patients with severe aplastic anemia is definite,and the side effects are relatively low,and the safety is relatively high.