神经外科术后颅内感染患者接受利奈唑胺治疗方案的疗效及安全性探讨

The Efficacy and Safety of Linezolid Treatment in Patients with Intracranial Infection after Neurosurgery

目的探究神经外科术后颅内感染患者行利奈唑胺治疗方案的疗效和安全性。方法采用回顾性分析方法,选择该院神经外科2017年1月—2019年1月收治的术后颅内感染患者40例为研究对象,40例患者均接收利奈唑胺治疗方案,通过对比40例患者治疗前后各项临床症状变化情况、脑脊液指标变化情况,以及不良反应发生率,判断利奈唑胺治疗方案的治疗效果和安全性。结果神经外科术后颅内感染患者接收利奈唑胺治疗方案后,各项临床症状均出现好转,40例患者中仅有1例患者表现为“无效”,治疗总有效率为97.5%;接受治疗1周后,患者脑脊液白细胞指标为(92.34±22.63)×106/L,葡萄糖指标(4.12±2.17)mmol/L,多核白细胞比例(11.27±1.44)%。优于治疗前的(1461.51±351.02)×106/L、(1.70±0.12)mmol/L、(72.34±12.31)%,差异有统计学意义(t=24.618、7.042、31.163,P<0.05);不良反应发生率为0.0%。结论神经外科术后颅内感染患者行利奈唑胺治疗方案,可有效改善患者各项临床症状,调节脑脊液指标,且不良反应发生率低,具有较好的疗效和安全性。

Objective To explore the efficacy and safety of linezolid treatment in patients with intracranial infection after neurosurgery.Methods Using retrospective analysis methods,40 patients with postoperative intracranial infection received from January 2017 to January 2019 in the hospital were selected as the research objects.40 patients all received linezolid treatment plan.Through comparison,patients before and after treatment,changes in various clinical symptoms,changes in cerebrospinal fluid indicators,and incidence of adverse reactions were used to determine the therapeutic effect and safety of linezolid treatment.Results After neurosurgery patients with intracranial infection received linezolid treatment,their clinical symptoms improved.Only 1 of 40 patients showed"ineffective",and the total effective rate of treatment was 97.5%;after one week of treatment,the patient's cerebrospinal fluid white blood cell index was(92.34±22.63)×106/L,glucose index(4.12±2.17)mmol/L,and multinucleated white blood cell ratio(11.27±1.44)%.Better than the pre-treatment(1461.51±351.02)×106/L,(1.70±0.12)mmol/L,(72.34±12.31)%,the difference was statistically significant(t=24.618,7.042,31.163,P<0.05).The incidence of adverse reactions was 0.0%.Conclusion Linezolid treatment for patients with intracranial infection after neurosurgery can effectively improve the clinical symptoms of the patients,adjust the cerebrospinal fluid indicators,and have a low incidence of adverse reactions.It has good efficacy and safety.